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Inhibition of in vitro anti-DNA B-cell responses by cyclosporine.

Publication ,  Journal Article
Mayus, JL; Semper, KF; Pisetsky, DS
Published in: Cell Immunol
August 1985

The action of the immunosuppressive agent cyclosporine (CsA) on anti-DNA B-cell responses was investigated in an in vitro system. Spleen cells from autoimmune MRL-lpr/lpr or control BALB/c mice, when cultured at high cell density, spontaneously produced significant amounts of IgM and IgG, including anti-DNA. IgG levels, both total and anti-DNA, were much higher for MRL-lpr/lpr cells compared to BALB/c cells, suggesting similarity of this model system to the in vivo response. For cells of both strains, the production of IgM and IgG anti-DNA was 10- to 100-fold more sensitive to the inhibitory activity of CsA than total immunoglobulin production. The effect was not manifest, however, in cultures stimulated with the B-cell mitogen, lipopolysaccharide. These observations suggest that CsA in certain dose ranges preferentially inhibits anti-DNA production, with efficacy determined by the mechanisms promoting B-cell hyperactivity.

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Published In

Cell Immunol

DOI

ISSN

0008-8749

Publication Date

August 1985

Volume

94

Issue

1

Start / End Page

195 / 204

Location

Netherlands

Related Subject Headings

  • T-Lymphocytes
  • Mice, Inbred Strains
  • Mice
  • Male
  • Lymphocyte Activation
  • In Vitro Techniques
  • Immunology
  • DNA
  • Cyclosporins
  • Cells, Cultured
 

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Mayus, J. L., Semper, K. F., & Pisetsky, D. S. (1985). Inhibition of in vitro anti-DNA B-cell responses by cyclosporine. Cell Immunol, 94(1), 195–204. https://doi.org/10.1016/0008-8749(85)90096-6
Mayus, J. L., K. F. Semper, and D. S. Pisetsky. “Inhibition of in vitro anti-DNA B-cell responses by cyclosporine.Cell Immunol 94, no. 1 (August 1985): 195–204. https://doi.org/10.1016/0008-8749(85)90096-6.
Mayus JL, Semper KF, Pisetsky DS. Inhibition of in vitro anti-DNA B-cell responses by cyclosporine. Cell Immunol. 1985 Aug;94(1):195–204.
Mayus, J. L., et al. “Inhibition of in vitro anti-DNA B-cell responses by cyclosporine.Cell Immunol, vol. 94, no. 1, Aug. 1985, pp. 195–204. Pubmed, doi:10.1016/0008-8749(85)90096-6.
Mayus JL, Semper KF, Pisetsky DS. Inhibition of in vitro anti-DNA B-cell responses by cyclosporine. Cell Immunol. 1985 Aug;94(1):195–204.
Journal cover image

Published In

Cell Immunol

DOI

ISSN

0008-8749

Publication Date

August 1985

Volume

94

Issue

1

Start / End Page

195 / 204

Location

Netherlands

Related Subject Headings

  • T-Lymphocytes
  • Mice, Inbred Strains
  • Mice
  • Male
  • Lymphocyte Activation
  • In Vitro Techniques
  • Immunology
  • DNA
  • Cyclosporins
  • Cells, Cultured