Direct detection of cellular immune responses to cancer vaccines.
Publication
, Journal Article
Mosca, PJ; Hobeika, AC; Clay, TM; Morse, MA; Lyerly, HK
Published in: Surgery
March 2001
The evaluation of cancer immunotherapy is predicated on the hypothesis that markers of tumor antigen-specific T-cell immunity will cone-late with clinical efficacy. Establishing which candidate vaccines should enter large-scale clinical trials will necessitate optimal application of immunologic monitoring assays. Evidence suggests that available techniques are adequate for the direct detection of clinically significant antigen-specific T-cell responses from tissue specimens. To achieve this goal, it is important to have an understanding of individual methods and their limitations, to include appropriate control antigens in the monitoring strategy, and to incorporate statistical considerations into the design and analysis of such studies.
Duke Scholars
Published In
Surgery
DOI
ISSN
0039-6060
Publication Date
March 2001
Volume
129
Issue
3
Start / End Page
248 / 254
Location
United States
Related Subject Headings
- T-Lymphocytes
- Surgery
- Immunity, Cellular
- Humans
- Epitopes
- Cancer Vaccines
- 3202 Clinical sciences
- 1103 Clinical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Mosca, P. J., Hobeika, A. C., Clay, T. M., Morse, M. A., & Lyerly, H. K. (2001). Direct detection of cellular immune responses to cancer vaccines. Surgery, 129(3), 248–254. https://doi.org/10.1067/msy.2001.108609
Mosca, P. J., A. C. Hobeika, T. M. Clay, M. A. Morse, and H. K. Lyerly. “Direct detection of cellular immune responses to cancer vaccines.” Surgery 129, no. 3 (March 2001): 248–54. https://doi.org/10.1067/msy.2001.108609.
Mosca PJ, Hobeika AC, Clay TM, Morse MA, Lyerly HK. Direct detection of cellular immune responses to cancer vaccines. Surgery. 2001 Mar;129(3):248–54.
Mosca, P. J., et al. “Direct detection of cellular immune responses to cancer vaccines.” Surgery, vol. 129, no. 3, Mar. 2001, pp. 248–54. Pubmed, doi:10.1067/msy.2001.108609.
Mosca PJ, Hobeika AC, Clay TM, Morse MA, Lyerly HK. Direct detection of cellular immune responses to cancer vaccines. Surgery. 2001 Mar;129(3):248–254.
Published In
Surgery
DOI
ISSN
0039-6060
Publication Date
March 2001
Volume
129
Issue
3
Start / End Page
248 / 254
Location
United States
Related Subject Headings
- T-Lymphocytes
- Surgery
- Immunity, Cellular
- Humans
- Epitopes
- Cancer Vaccines
- 3202 Clinical sciences
- 1103 Clinical Sciences