Direct detection of cellular immune responses to cancer vaccines.


Journal Article (Review)

The evaluation of cancer immunotherapy is predicated on the hypothesis that markers of tumor antigen-specific T-cell immunity will cone-late with clinical efficacy. Establishing which candidate vaccines should enter large-scale clinical trials will necessitate optimal application of immunologic monitoring assays. Evidence suggests that available techniques are adequate for the direct detection of clinically significant antigen-specific T-cell responses from tissue specimens. To achieve this goal, it is important to have an understanding of individual methods and their limitations, to include appropriate control antigens in the monitoring strategy, and to incorporate statistical considerations into the design and analysis of such studies.

Full Text

Duke Authors

Cited Authors

  • Mosca, PJ; Hobeika, AC; Clay, TM; Morse, MA; Lyerly, HK

Published Date

  • March 2001

Published In

Volume / Issue

  • 129 / 3

Start / End Page

  • 248 - 254

PubMed ID

  • 11231452

Pubmed Central ID

  • 11231452

International Standard Serial Number (ISSN)

  • 0039-6060

Digital Object Identifier (DOI)

  • 10.1067/msy.2001.108609


  • eng

Conference Location

  • United States