Immune monitoring.


Journal Article (Review)

A wide array of immunologic tests are available for immune monitoring in cancer vaccine trials, and the number of novel assays and technical modifications continues to burgeon. Because only a small fraction of all proposed vaccine trials tested in phase I-II trials, for practical reasons, will ultimately move forward to be tested in phase III trials, there must be a system of establishing the most promising immunization strategies. This evaluation of cancer vaccine will require standardization of the immune assays and statistical methods used in immunologic monitoring. Furthermore, the use of a systematic approach to evaluating and adopting novel technologies for immunologic assessment would likely lead to timely implementation of more reliable, practical and cost-effective methods of immune. It should be the goal and expectation that this rational approach to immune monitoring will allow the critical appraisal of the most promising vaccine candidates in the context of pivotal, multi-center trials.

Full Text

Duke Authors

Cited Authors

  • Mosca, PJ; Clay, TM; Morse, MA; Lyerly, HK

Published Date

  • 2005

Published In

Volume / Issue

  • 123 /

Start / End Page

  • 369 - 388

PubMed ID

  • 16211879

Pubmed Central ID

  • 16211879

International Standard Serial Number (ISSN)

  • 0927-3042

Digital Object Identifier (DOI)

  • 10.1007/0-387-27545-2_16


  • eng

Conference Location

  • United States