Reversible cardiac dysfunction associated with pandemic 2009 influenza A(H1N1).

Journal Article (Journal Article)

Historical influenza A epidemics have carried elevated rates of cardiovascular disease, including transient cardiac dysfunction. Whether such an association holds for the novel influenza A strain, pandemic 2009 influenza A(H1N1) [A(H1N1)], remains unknown. We report an index case of transient cardiac dysfunction associated with A(H1N1) infection. Next, we reviewed 123 sequential cases of patients hospitalized with pandemic A(H1N1) at a single academic medical center in the United States from April 1, 2009, through October 31, 2009. We identified that 4.9% (6/123) of patients had either new or worsened left ventricular dysfunction. These cases ranged in age from 23 to 51 years, and all had preexisting medical conditions. ICU level care was required in 83% (5/6) of the cases. Sixty-seven percent (4/6) of the cases had follow-up echocardiograms, and left ventricular function improved in all four. We conclude that potentially reversible cardiac dysfunction is a relatively common complication associated with hospitalized pandemic A(H1N1) influenza.

Full Text

Duke Authors

Cited Authors

  • Martin, SS; Hollingsworth, CL; Norfolk, SG; Wolfe, CR; Hollingsworth, JW

Published Date

  • May 2010

Published In

Volume / Issue

  • 137 / 5

Start / End Page

  • 1195 - 1197

PubMed ID

  • 20139224

Pubmed Central ID

  • PMC2862401

Electronic International Standard Serial Number (EISSN)

  • 1931-3543

Digital Object Identifier (DOI)

  • 10.1378/chest.10-0032


  • eng

Conference Location

  • United States