Alterations of the B-cell response by HIV-1 replication.

Published

Journal Article

While the hallmark of HIV-1 infection is the progressive depletion of CD4(+) T cells, extensive B-cell dysfunction ensues that impairs the quality of the humoral response. HIV-1 infection causes hypergammaglobulinemia, polyclonal activation, loss of memory B-cell subsets, B-cell exhaustion, aberrant B-cell surface markers, and impaired humoral responses against infections and vaccinations. The totality of the mechanisms that contribute to B-cell dysfunction in vivo is unknown, although roles for HIV proteins (Env, Tat, and Nef) and virions binding to CD21 on B cells have been identified. Recent studies suggest that early antiretroviral therapy, that minimizes virus replication, can profoundly preserve the early B-cell response to HIV-1. Thus, it is clear that there is an intricate interplay between HIV replication and stimulation of the host B-cell response to infection. A better understanding of how HIV-1 subverts a productive B-cell response is needed to inform vaccine strategies that aim to elicit long-lived plasma cells and memory B-cell responses that can act quickly upon antigen stimulation.

Full Text

Duke Authors

Cited Authors

  • Shen, X; Tomaras, GD

Published Date

  • March 2011

Published In

Volume / Issue

  • 8 / 1

Start / End Page

  • 23 - 30

PubMed ID

  • 21161615

Pubmed Central ID

  • 21161615

Electronic International Standard Serial Number (EISSN)

  • 1548-3576

International Standard Serial Number (ISSN)

  • 1548-3568

Digital Object Identifier (DOI)

  • 10.1007/s11904-010-0064-2

Language

  • eng