Clinical presentation and natural history of patients with essential thrombocythemia and the Philadelphia chromosome.


Journal Article

Six women presented with the clinical picture of essential thrombocythemia (ET) without the anemia, marked splenomegaly, and extreme leukocytosis characteristic of chronic myelogenous leukemia (CML). All had the Philadelphia chromosome on karyotype analysis of the bone marrow. Peripheral basophilia was present in four cases, providing a clinical clue that the Philadelphia chromosome might be present. Marrow biopsy showed granulocytic hyperplasia and either small megakaryocytes or sheets of megakaryocytes with marked atypia, findings that are more typical of CML than ET. The clinical importance of finding the Philadelphia chromosome in patients who seem to have ET is in assessing prognosis. ET generally follows a chronic, indolent course. However, five of these six patients who had the Philadelphia chromosome underwent clinical transition to the accelerated phase of CML or blastic leukemia in 4-7 years.

Full Text

Cited Authors

  • Stoll, DB; Peterson, P; Exten, R; Laszlo, J; Pisciotta, AV; Ellis, JT; White, P; Vaidya, K; Bozdech, M; Murphy, S

Published Date

  • February 1, 1988

Published In

Volume / Issue

  • 27 / 2

Start / End Page

  • 77 - 83

PubMed ID

  • 3422539

Pubmed Central ID

  • 3422539

Electronic International Standard Serial Number (EISSN)

  • 1096-8652

International Standard Serial Number (ISSN)

  • 0361-8609

Digital Object Identifier (DOI)

  • 10.1002/ajh.2830270202


  • eng