Screening experiments and the use of fractional factorial designs in behavioral intervention research.

Journal Article (Journal Article)

Health behavior intervention studies have focused primarily on comparing new programs and existing programs via randomized controlled trials. However, numbers of possible components (factors) are increasing dramatically as a result of developments in science and technology (e.g., Web-based surveys). These changes dictate the need for alternative methods that can screen and quickly identify a large set of potentially important treatment components. We have developed and implemented a multiphase experimentation strategy for accomplishing this goal. We describe the screening phase of this strategy and the use of fractional factorial designs (FFDs) in studying several components economically. We then use 2 ongoing behavioral intervention projects to illustrate the usefulness of FFDs. FFDs should be supplemented with follow-up experiments in the refining phase so any critical assumptions about interactions can be verified.

Full Text

Duke Authors

Cited Authors

  • Nair, V; Strecher, V; Fagerlin, A; Ubel, P; Resnicow, K; Murphy, S; Little, R; Chakraborty, B; Zhang, A

Published Date

  • August 2008

Published In

Volume / Issue

  • 98 / 8

Start / End Page

  • 1354 - 1359

PubMed ID

  • 18556602

Pubmed Central ID

  • PMC2446451

Electronic International Standard Serial Number (EISSN)

  • 1541-0048

International Standard Serial Number (ISSN)

  • 0090-0036

Digital Object Identifier (DOI)

  • 10.2105/ajph.2007.127563


  • eng