Influence of lemakalim on the pulmonary vascular bed of the cat.
Pulmonary vascular responses to the K+ATP channel opener, lemakalim, were investigated in the intact-chest cat under constant flow conditions. When tone in the pulmonary vascular bed was elevated, intralobar injections of lemakalim caused dose-related decreases in lobar arterial pressure without changing left atrial pressure. Lemakalim was approximately 3-fold more potent than cromakalim in dilating the pulmonary vascular bed, and pulmonary vasodilator responses to these K+ATP channel openers were blocked by the K+ATP channel blocking agent, glybenclamide. Glybenclamide had no significant effect on pulmonary vasodilator responses to acetylcholine or vasoactive intestinal peptide (VIP) but decreased responses to calcitonin gene-related peptide (CGRP). These data show that lemakalim has potent pulmonary vasodilator activity and suggest that responses are due to activation of a glybenclamide-sensitive K+ATP channel.
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Related Subject Headings
- Vasodilator Agents
- Vasoactive Intestinal Peptide
- Pyrroles
- Pulmonary Circulation
- Pharmacology & Pharmacy
- Perfusion
- Male
- Hydrogen-Ion Concentration
- Glyburide
- Female
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Vasodilator Agents
- Vasoactive Intestinal Peptide
- Pyrroles
- Pulmonary Circulation
- Pharmacology & Pharmacy
- Perfusion
- Male
- Hydrogen-Ion Concentration
- Glyburide
- Female