Influence of lemakalim on the pulmonary vascular bed of the cat.
Journal Article (Journal Article)
Pulmonary vascular responses to the K+ATP channel opener, lemakalim, were investigated in the intact-chest cat under constant flow conditions. When tone in the pulmonary vascular bed was elevated, intralobar injections of lemakalim caused dose-related decreases in lobar arterial pressure without changing left atrial pressure. Lemakalim was approximately 3-fold more potent than cromakalim in dilating the pulmonary vascular bed, and pulmonary vasodilator responses to these K+ATP channel openers were blocked by the K+ATP channel blocking agent, glybenclamide. Glybenclamide had no significant effect on pulmonary vasodilator responses to acetylcholine or vasoactive intestinal peptide (VIP) but decreased responses to calcitonin gene-related peptide (CGRP). These data show that lemakalim has potent pulmonary vasodilator activity and suggest that responses are due to activation of a glybenclamide-sensitive K+ATP channel.
Full Text
Duke Authors
Cited Authors
- Hood, JS; McMahon, TJ; Kadowitz, PJ
Published Date
- September 4, 1991
Published In
Volume / Issue
- 202 / 1
Start / End Page
- 101 - 104
PubMed ID
- 1786796
International Standard Serial Number (ISSN)
- 0014-2999
Digital Object Identifier (DOI)
- 10.1016/0014-2999(91)90260-w
Language
- eng
Conference Location
- Netherlands