Influence of lemakalim on the pulmonary vascular bed of the cat.

Published

Journal Article

Pulmonary vascular responses to the K+ATP channel opener, lemakalim, were investigated in the intact-chest cat under constant flow conditions. When tone in the pulmonary vascular bed was elevated, intralobar injections of lemakalim caused dose-related decreases in lobar arterial pressure without changing left atrial pressure. Lemakalim was approximately 3-fold more potent than cromakalim in dilating the pulmonary vascular bed, and pulmonary vasodilator responses to these K+ATP channel openers were blocked by the K+ATP channel blocking agent, glybenclamide. Glybenclamide had no significant effect on pulmonary vasodilator responses to acetylcholine or vasoactive intestinal peptide (VIP) but decreased responses to calcitonin gene-related peptide (CGRP). These data show that lemakalim has potent pulmonary vasodilator activity and suggest that responses are due to activation of a glybenclamide-sensitive K+ATP channel.

Full Text

Duke Authors

Cited Authors

  • Hood, JS; McMahon, TJ; Kadowitz, PJ

Published Date

  • September 4, 1991

Published In

Volume / Issue

  • 202 / 1

Start / End Page

  • 101 - 104

PubMed ID

  • 1786796

Pubmed Central ID

  • 1786796

International Standard Serial Number (ISSN)

  • 0014-2999

Language

  • eng

Conference Location

  • Netherlands