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Differential effects of PACAP and VIP on the pulmonary and hindquarters vascular beds of the cat.

Publication ,  Journal Article
Minkes, RK; McMahon, TJ; Hood, JS; Murphy, WA; Coy, DH; McNamara, DB; Kadowitz, PJ
Published in: J Appl Physiol (1985)
March 1992

Responses to pituitary adenylate cyclase-activating polypeptide (PACAP), a novel peptide derived from ovine hypothalamus with 68% sequence homology with vasoactive intestinal polypeptide (VIP), were investigated in the pulmonary and hindquarters vascular beds of the anesthetized cat under conditions of controlled blood flow. Injection of the peptide into the perfused lung lobe under elevated tone conditions produced dose-dependent decreases in lobar arterial pressure that were accompanied by biphasic changes in systemic arterial pressure characterized by an initial decrease followed by a secondary increase in pressure. When compared with other vasodilator agents in the pulmonary vascular bed, the relative order of potency was isoproterenol greater than PACAP greater than acetylcholine greater than calcitonin gene-related peptide greater than VIP. In the hindquarters vascular bed, intra-arterial injections of PACAP produced biphasic changes in hindquarters perfusion pressure characterized by initial decreases followed by secondary increases, which were accompanied by biphasic changes in systemic arterial pressure. In terms of relative vasodilator activity in the hindlimb, the order of relative potency was isoproterenol greater than acetylcholine greater than calcitonin gene-related peptide greater than VIP greater than PACAP. PACAP was the only agent that caused a secondary vasoconstrictor response in the hindlimb and produced biphasic changes in systemic arterial pressure. D-Phe2-VIP, a VIP receptor antagonist, blocked the hindquarters vasodilation in response to VIP but had no effect on responses to PACAP. The present investigation shows that PACAP produces pulmonary vasodilation, as well as dilation, and vasoconstriction in the systemic (hindlimb) vascular bed.(ABSTRACT TRUNCATED AT 250 WORDS)

Duke Scholars

Published In

J Appl Physiol (1985)

DOI

ISSN

8750-7587

Publication Date

March 1992

Volume

72

Issue

3

Start / End Page

1212 / 1217

Location

United States

Related Subject Headings

  • Vasoconstriction
  • Vasoactive Intestinal Peptide
  • Pulmonary Circulation
  • Pituitary Adenylate Cyclase-Activating Polypeptide
  • Physiology
  • Neuropeptides
  • Male
  • Hemodynamics
  • Female
  • Cats
 

Citation

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Minkes, R. K., McMahon, T. J., Hood, J. S., Murphy, W. A., Coy, D. H., McNamara, D. B., & Kadowitz, P. J. (1992). Differential effects of PACAP and VIP on the pulmonary and hindquarters vascular beds of the cat. J Appl Physiol (1985), 72(3), 1212–1217. https://doi.org/10.1152/jappl.1992.72.3.1212
Minkes, R. K., T. J. McMahon, J. S. Hood, W. A. Murphy, D. H. Coy, D. B. McNamara, and P. J. Kadowitz. “Differential effects of PACAP and VIP on the pulmonary and hindquarters vascular beds of the cat.J Appl Physiol (1985) 72, no. 3 (March 1992): 1212–17. https://doi.org/10.1152/jappl.1992.72.3.1212.
Minkes RK, McMahon TJ, Hood JS, Murphy WA, Coy DH, McNamara DB, et al. Differential effects of PACAP and VIP on the pulmonary and hindquarters vascular beds of the cat. J Appl Physiol (1985). 1992 Mar;72(3):1212–7.
Minkes, R. K., et al. “Differential effects of PACAP and VIP on the pulmonary and hindquarters vascular beds of the cat.J Appl Physiol (1985), vol. 72, no. 3, Mar. 1992, pp. 1212–17. Pubmed, doi:10.1152/jappl.1992.72.3.1212.
Minkes RK, McMahon TJ, Hood JS, Murphy WA, Coy DH, McNamara DB, Kadowitz PJ. Differential effects of PACAP and VIP on the pulmonary and hindquarters vascular beds of the cat. J Appl Physiol (1985). 1992 Mar;72(3):1212–1217.

Published In

J Appl Physiol (1985)

DOI

ISSN

8750-7587

Publication Date

March 1992

Volume

72

Issue

3

Start / End Page

1212 / 1217

Location

United States

Related Subject Headings

  • Vasoconstriction
  • Vasoactive Intestinal Peptide
  • Pulmonary Circulation
  • Pituitary Adenylate Cyclase-Activating Polypeptide
  • Physiology
  • Neuropeptides
  • Male
  • Hemodynamics
  • Female
  • Cats