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Analysis of responses to sarafotoxin 6a and sarafotoxin 6c in the pulmonary vascular bed of the cat.

Publication ,  Journal Article
McMahon, TJ; Hood, JS; Kadowitz, PJ
Published in: J Appl Physiol (1985)
November 1991

Pulmonary vascular responses to sarafotoxins 6a and 6c (S6a and S6c) were investigated in the intact-chest cat under constant flow conditions. Injections of S6a and S6c into the perfused lobar artery caused dose-related increases in lobar arterial pressure, increased left atrial pressure, and produced biphasic changes in systemic arterial (aortic) pressure. When left atrial pressure was maintained constant, injections of S6a, S6c, and endothelin 1 (ET-1) caused dose-related increases in lobar arterial pressure. The increases in lobar arterial pressure in response to S6a and S6c were not altered by treatment with a cyclooxygenase inhibitor or a thromboxane receptor blocking agent. Increases in lobar arterial pressure in response to S6a and S6c were not altered when airflow to the left lower lung lobe was interrupted by bronchial occlusion, and pressor responses were not diminished when the left lower lobe was perfused with low-molecular-weight dextran. Under conditions of controlled blood flow and constant left atrial pressure, S6a, S6b, S6c, and ET-1 had similar pressor activity, whereas the thromboxane A2 mimic, U-46619, had far greater activity when compared on a nanomolar basis. The present studies demonstrate that S6a and S6c have significant vasoconstrictor activity in the feline pulmonary vascular bed. These data suggest that pulmonary vasoconstrictor responses to the endothelin peptides are not dependent on release of cyclooxygenase products and the activation of thromboxane A2 receptors, alterations in bronchomotor tone, or interaction with formed elements in blood.

Duke Scholars

Published In

J Appl Physiol (1985)

DOI

ISSN

8750-7587

Publication Date

November 1991

Volume

71

Issue

5

Start / End Page

2019 / 2025

Location

United States

Related Subject Headings

  • Viper Venoms
  • Vasoconstriction
  • Thromboxane A2
  • Sequence Homology, Nucleic Acid
  • Respiration, Artificial
  • Pulmonary Circulation
  • Prostaglandin-Endoperoxide Synthases
  • Physiology
  • Perfusion
  • Molecular Sequence Data
 

Citation

APA
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ICMJE
MLA
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McMahon, T. J., Hood, J. S., & Kadowitz, P. J. (1991). Analysis of responses to sarafotoxin 6a and sarafotoxin 6c in the pulmonary vascular bed of the cat. J Appl Physiol (1985), 71(5), 2019–2025. https://doi.org/10.1152/jappl.1991.71.5.2019
McMahon, T. J., J. S. Hood, and P. J. Kadowitz. “Analysis of responses to sarafotoxin 6a and sarafotoxin 6c in the pulmonary vascular bed of the cat.J Appl Physiol (1985) 71, no. 5 (November 1991): 2019–25. https://doi.org/10.1152/jappl.1991.71.5.2019.
McMahon TJ, Hood JS, Kadowitz PJ. Analysis of responses to sarafotoxin 6a and sarafotoxin 6c in the pulmonary vascular bed of the cat. J Appl Physiol (1985). 1991 Nov;71(5):2019–25.
McMahon, T. J., et al. “Analysis of responses to sarafotoxin 6a and sarafotoxin 6c in the pulmonary vascular bed of the cat.J Appl Physiol (1985), vol. 71, no. 5, Nov. 1991, pp. 2019–25. Pubmed, doi:10.1152/jappl.1991.71.5.2019.
McMahon TJ, Hood JS, Kadowitz PJ. Analysis of responses to sarafotoxin 6a and sarafotoxin 6c in the pulmonary vascular bed of the cat. J Appl Physiol (1985). 1991 Nov;71(5):2019–2025.

Published In

J Appl Physiol (1985)

DOI

ISSN

8750-7587

Publication Date

November 1991

Volume

71

Issue

5

Start / End Page

2019 / 2025

Location

United States

Related Subject Headings

  • Viper Venoms
  • Vasoconstriction
  • Thromboxane A2
  • Sequence Homology, Nucleic Acid
  • Respiration, Artificial
  • Pulmonary Circulation
  • Prostaglandin-Endoperoxide Synthases
  • Physiology
  • Perfusion
  • Molecular Sequence Data