Innate immunity and the lung: defense at the interface between host and environment.

Journal Article (Journal Article;Review)

The lung serves as a major interface between the host and the external environment. As such, numerous lines of defense protect the host from inhaled potential pathogens. A breach in pulmonary innate immunity can lead to deleterious outcomes, such as pneumonia and disseminated infection. Pulmonary innate immunity, the first line of defense, is mediated by airway and alveolar epithelial cells as well as resident and recruited leukocytes. This article will discuss the key cellular and secreted components of the pulmonary innate immune system.

Full Text

Duke Authors

Cited Authors

  • Zaas, AK; Schwartz, DA

Published Date

  • August 2005

Published In

Volume / Issue

  • 15 / 6

Start / End Page

  • 195 - 202

PubMed ID

  • 16182128

International Standard Serial Number (ISSN)

  • 1050-1738

Digital Object Identifier (DOI)

  • 10.1016/j.tcm.2005.07.001


  • eng

Conference Location

  • United States