The effect of toll-like receptors and toll-like receptor genetics in human disease.


Journal Article (Review)

Toll-like receptors (TLRs) enable innate immune recognition of endogenous and exogenous prototypic ligands. They also orchestrate innate and adaptive immune response to infection, inflammation, and tissue injury. Given their significance in the immune response, it is not surprising that genetic variations of TLRs can affect their function and by extension affect the response of the organism to environmental stimuli. The genetics of TLRs provides important insights in gene-environment interactions in health and disease, and it may enable scientists to assess patients' susceptibility to diseases or predict their response to treatments.

Full Text

Duke Authors

Cited Authors

  • Garantziotis, S; Hollingsworth, JW; Zaas, AK; Schwartz, DA

Published Date

  • 2008

Published In

Volume / Issue

  • 59 /

Start / End Page

  • 343 - 359

PubMed ID

  • 17845139

Pubmed Central ID

  • 17845139

International Standard Serial Number (ISSN)

  • 0066-4219

Digital Object Identifier (DOI)

  • 10.1146/


  • eng

Conference Location

  • United States