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Prevalence of iron deficiency in children with Down syndrome.

Publication ,  Journal Article
Dixon, NE; Crissman, BG; Smith, PB; Zimmerman, SA; Worley, G; Kishnani, PS
Published in: J Pediatr
December 2010

OBJECTIVES: To determine the prevalence of iron deficiency (ID) and iron deficiency anemia (IDA) in a sample of children with Down syndrome (DS) and to evaluate the effect of macrocytosis on the diagnosis of ID/IDA in these children. STUDY DESIGN: Children with DS ≥ 12 months of age who were followed at the Duke University Medical Center Comprehensive DS Clinic from December 2004 to March 2007 were screened for ID/IDA with a complete blood count, reticulocyte count, iron panel, and erythrocytic protoporphyrins. RESULTS: A total of 114 children were enrolled, with a median age of 4.7 years. ID was identified in 12 subjects (10%), and IDA was identified in 3 subjects (3%). ID/IDA would not have been accurately diagnosed in 13 of 15 subjects (86%) if red blood cell (RBC) indices alone had been used for screening. Abnormal RBC indices with low transferrin saturation were 100% sensitive for ID/ IDA screening. CONCLUSIONS: Prevalence of ID/IDA in children with DS was comparable with that in the general pediatric population. Macrocytosis had implications for screening of ID/IDA with only RBC indices. We suggest ID/IDA screening in DS children be done with a laboratory panel at least including complete blood count, reticulocyte count, transferrin saturation, and serum ferritin.

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Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

December 2010

Volume

157

Issue

6

Start / End Page

967 / 971.e1

Location

United States

Related Subject Headings

  • Young Adult
  • Prospective Studies
  • Prevalence
  • Pediatrics
  • Male
  • Iron Deficiencies
  • Infant
  • Humans
  • Female
  • Down Syndrome
 

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Dixon, N. E., Crissman, B. G., Smith, P. B., Zimmerman, S. A., Worley, G., & Kishnani, P. S. (2010). Prevalence of iron deficiency in children with Down syndrome. J Pediatr, 157(6), 967-971.e1. https://doi.org/10.1016/j.jpeds.2010.06.011
Dixon, Natalia E., Blythe G. Crissman, P Brian Smith, Sherri A. Zimmerman, Gordon Worley, and Priya S. Kishnani. “Prevalence of iron deficiency in children with Down syndrome.J Pediatr 157, no. 6 (December 2010): 967-971.e1. https://doi.org/10.1016/j.jpeds.2010.06.011.
Dixon NE, Crissman BG, Smith PB, Zimmerman SA, Worley G, Kishnani PS. Prevalence of iron deficiency in children with Down syndrome. J Pediatr. 2010 Dec;157(6):967-971.e1.
Dixon, Natalia E., et al. “Prevalence of iron deficiency in children with Down syndrome.J Pediatr, vol. 157, no. 6, Dec. 2010, pp. 967-971.e1. Pubmed, doi:10.1016/j.jpeds.2010.06.011.
Dixon NE, Crissman BG, Smith PB, Zimmerman SA, Worley G, Kishnani PS. Prevalence of iron deficiency in children with Down syndrome. J Pediatr. 2010 Dec;157(6):967-971.e1.
Journal cover image

Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

December 2010

Volume

157

Issue

6

Start / End Page

967 / 971.e1

Location

United States

Related Subject Headings

  • Young Adult
  • Prospective Studies
  • Prevalence
  • Pediatrics
  • Male
  • Iron Deficiencies
  • Infant
  • Humans
  • Female
  • Down Syndrome