Skip to main content

Inflammatory biomarkers in heart failure.

Publication ,  Journal Article
Petersen, JW; Felker, GM
Published in: Congest Heart Fail
2006

Multiple lines of evidence support the "cytokine hypothesis," which suggests that inflammation plays an important role in the development and progression of heart failure. Circulating markers of inflammation, such as tumor necrosis factor alpha, interleukin 6, and C-reactive protein, may be useful in establishing the diagnosis, gauging prognosis, and evaluating the response to therapy in patients with heart failure. In addition to their potential as heart failure biomarkers, inflammatory cytokines have been investigated as targets of heart failure therapy. Although results for therapies directed against specific cytokines (such as tumor necrosis factor alpha) have thus far been disappointing, multiple studies continue to address the therapeutic potential of modulating the immune response in heart failure. In this review, the authors analyze available data supporting the use of inflammatory markers both as biomarkers and as potential therapeutic targets.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Congest Heart Fail

DOI

ISSN

1527-5299

Publication Date

2006

Volume

12

Issue

6

Start / End Page

324 / 328

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Receptors, Tumor Necrosis Factor, Type II
  • Receptors, Tumor Necrosis Factor, Type I
  • Receptors, Tumor Necrosis Factor
  • Prognosis
  • Interleukin-6
  • Immunoglobulin G
  • Humans
  • Heart Failure
  • Etanercept
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Petersen, J. W., & Felker, G. M. (2006). Inflammatory biomarkers in heart failure. Congest Heart Fail, 12(6), 324–328. https://doi.org/10.1111/j.1527-5299.2006.05595.x
Petersen, John W., and G Michael Felker. “Inflammatory biomarkers in heart failure.Congest Heart Fail 12, no. 6 (2006): 324–28. https://doi.org/10.1111/j.1527-5299.2006.05595.x.
Petersen JW, Felker GM. Inflammatory biomarkers in heart failure. Congest Heart Fail. 2006;12(6):324–8.
Petersen, John W., and G. Michael Felker. “Inflammatory biomarkers in heart failure.Congest Heart Fail, vol. 12, no. 6, 2006, pp. 324–28. Pubmed, doi:10.1111/j.1527-5299.2006.05595.x.
Petersen JW, Felker GM. Inflammatory biomarkers in heart failure. Congest Heart Fail. 2006;12(6):324–328.

Published In

Congest Heart Fail

DOI

ISSN

1527-5299

Publication Date

2006

Volume

12

Issue

6

Start / End Page

324 / 328

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Receptors, Tumor Necrosis Factor, Type II
  • Receptors, Tumor Necrosis Factor, Type I
  • Receptors, Tumor Necrosis Factor
  • Prognosis
  • Interleukin-6
  • Immunoglobulin G
  • Humans
  • Heart Failure
  • Etanercept