The immune response during acute HIV-1 infection: clues for vaccine development.

Published

Journal Article (Review)

The early immune response to HIV-1 infection is likely to be an important factor in determining the clinical course of disease. Recent data indicate that the HIV-1 quasispecies that arise following a mucosal infection are usually derived from a single transmitted virus. Moreover, the finding that the first effective immune responses drive the selection of virus escape mutations provides insight into the earliest immune responses against the transmitted virus and their contributions to the control of acute viraemia. Strong innate and adaptive immune responses occur subsequently but they are too late to eliminate the infection. In this Review, we discuss recent studies on the kinetics and quality of early immune responses to HIV-1 and their implications for developing a successful preventive HIV-1 vaccine.

Full Text

Duke Authors

Cited Authors

  • McMichael, AJ; Borrow, P; Tomaras, GD; Goonetilleke, N; Haynes, BF

Published Date

  • January 2010

Published In

Volume / Issue

  • 10 / 1

Start / End Page

  • 11 - 23

PubMed ID

  • 20010788

Pubmed Central ID

  • 20010788

Electronic International Standard Serial Number (EISSN)

  • 1474-1741

International Standard Serial Number (ISSN)

  • 1474-1733

Digital Object Identifier (DOI)

  • 10.1038/nri2674

Language

  • eng