HIV-1-specific antibody responses during acute and chronic HIV-1 infection.


Journal Article (Review)

PURPOSE OF REVIEW: The humoral immune response to HIV-1 throughout infection is comprised of complex mixtures of antibody isotypes with numerous HIV-1 specificities. However, unlike antibody responses to most infections, protective antibody responses are delayed and do not arise until long after HIV-1 latency is established. We review recent data on HIV-1-specific antibody isotypes induced following HIV-1 transmission: to understand the effects of HIV-1 on B cell and T cell effector responses, to understand the timing of the rise and fall of different anti-HIV-1 antibodies and to understand how antibodies could contribute to protective immunity if they were either pre-existing or elicited immediately after HIV-1 transmission. RECENT FINDINGS: Studies of the earliest events following infection by the transmitted/founder virus have recently revealed that early destruction of B cell generative microenvironments may be responsible for delay of potentially protective anti-HIV-1 antibody responses. Unlike the initial CD8 T cell response to HIV-1, the initial induced antibody response is usually ineffective in controlling virus replication during acute HIV-1 infection. SUMMARY: The antibody isotypes and specificities elicited during HIV-1 infection can provide a window into deciphering the detrimental effects of HIV-1 on B cell and T cell responses. Additionally, further characterization of the virus inhibitory capabilities of anti-HIV-1 antibody isotypes can define the spectrum of potential protective HIV-1 antibodies that could be readily elicited by experimental vaccines and adjuvants.

Full Text

Duke Authors

Cited Authors

  • Tomaras, GD; Haynes, BF

Published Date

  • September 2009

Published In

Volume / Issue

  • 4 / 5

Start / End Page

  • 373 - 379

PubMed ID

  • 20048700

Pubmed Central ID

  • 20048700

Electronic International Standard Serial Number (EISSN)

  • 1746-6318

Digital Object Identifier (DOI)

  • 10.1097/COH.0b013e32832f00c0


  • eng

Conference Location

  • United States