Naïve T cells are maintained in the periphery during the first 3 months of acute HIV-1 infection: implications for analysis of thymus function.

Published

Journal Article

A key determinant of T cell dynamics in HIV-1 infection is the status of thymic function. To date, most studies of the impact of HIV-1 on the thymus during early HIV-1 infection have been done in samples collected in the interval of 3-12 months after infection. In this study, we have probed the status of thymic function and peripheral naive T cells in patients with acute HIV-1 infection diagnosed 18-72 days after the onset of symptoms. We found that peripheral CD4 and CD8 T cell proliferation was initially elevated, then waned over time. The fall in T cell proliferation correlated with a reduction in HIV-1 viral RNA levels and a rise in peripheral blood CD4+ CD25+ T cells. In spite of elevated T cell proliferation early on in primary HIV-1 infection, levels of naive phenotype CD4 and CD8 T cells and T cell receptor excision circle positive cells (sjTREC(+)) remained constant. Taken together with the observation that T cell proliferation normally dilutes peripheral T cell episomal sjTREC levels, these data suggested that thymopoiesis contributes to maintenance of the naive T cell pool during the earliest stages of HIV-1 infection (18-72 days).

Full Text

Duke Authors

Cited Authors

  • Sempowski, GD; Hicks, CB; Eron, JJ; Bartlett, JA; Hale, LP; Ferrari, G; Edwards, LJ; Fiscus, S; Haynes, BF

Published Date

  • September 2005

Published In

Volume / Issue

  • 25 / 5

Start / End Page

  • 462 - 472

PubMed ID

  • 16160915

Pubmed Central ID

  • 16160915

Electronic International Standard Serial Number (EISSN)

  • 1573-2592

International Standard Serial Number (ISSN)

  • 0271-9142

Digital Object Identifier (DOI)

  • 10.1007/s10875-005-5635-4

Language

  • eng