Low-dose mucosal simian immunodeficiency virus infection restricts early replication kinetics and transmitted virus variants in rhesus monkeys.

Published

Journal Article

Defining the earliest virologic events following human immunodeficiency virus type 1 (HIV-1) transmission may be critical for the design of vaccine strategies aimed at blocking acquisition of HIV-1 infection. In particular, the length of the eclipse phase and the number of transmitted virus variants may define the window in which a prophylactic vaccine must act. Here we show that the dose of the virus inoculum affects these key virologic parameters following intrarectal simian immunodeficiency virus (SIV) infection of rhesus monkeys. Low-dose SIV infection resulted in a lengthened eclipse phase, fewer transmitted virus variants, and decreased innate immune activation compared with these parameters in high-dose SIV infection. These data suggest a mechanism by which it may be considerably easier for a vaccine to protect against low-risk HIV-1 transmission than against high-risk HIV-1 transmission. These findings have implications for the design and interpretation of HIV-1 vaccine efficacy studies.

Full Text

Duke Authors

Cited Authors

  • Liu, J; Keele, BF; Li, H; Keating, S; Norris, PJ; Carville, A; Mansfield, KG; Tomaras, GD; Haynes, BF; Kolodkin-Gal, D; Letvin, NL; Hahn, BH; Shaw, GM; Barouch, DH

Published Date

  • October 2010

Published In

Volume / Issue

  • 84 / 19

Start / End Page

  • 10406 - 10412

PubMed ID

  • 20686016

Pubmed Central ID

  • 20686016

Electronic International Standard Serial Number (EISSN)

  • 1098-5514

International Standard Serial Number (ISSN)

  • 0022-538X

Digital Object Identifier (DOI)

  • 10.1128/JVI.01155-10

Language

  • eng