A whole-genome association study of major determinants for host control of HIV-1.
(Journal Article;Multicenter Study)
Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection. One of these is found within an endogenous retroviral element and is associated with major histocompatibility allele human leukocyte antigen (HLA)-B*5701, whereas a second is located near the HLA-C gene. An additional analysis of the time to HIV disease progression implicated two genes, one of which encodes an RNA polymerase I subunit. These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents.
Fellay, J; Shianna, KV; Ge, D; Colombo, S; Ledergerber, B; Weale, M; Zhang, K; Gumbs, C; Castagna, A; Cossarizza, A; Cozzi-Lepri, A; De Luca, A; Easterbrook, P; Francioli, P; Mallal, S; Martinez-Picado, J; Miro, JM; Obel, N; Smith, JP; Wyniger, J; Descombes, P; Antonarakis, SE; Letvin, NL; McMichael, AJ; Haynes, BF; Telenti, A; Goldstein, DB
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