Skip to main content
Journal cover image

Genome-wide linkage screen in familial Parkinson disease identifies loci on chromosomes 3 and 18.

Publication ,  Journal Article
Gao, X; Martin, ER; Liu, Y; Mayhew, G; Vance, JM; Scott, WK
Published in: Am J Hum Genet
April 2009

Parkinson disease (PD) is a complex, multifactorial neurodegenerative disease with substantial evidence for genetic risk factors. We conducted a genome-wide linkage screen of 5824 single-nucleotide polymorphisms in 278 families of European, non-Hispanic descent to localize regions that harbor susceptibility loci for PD. By using parametric and nonparametric linkage analyses and allowing for genetic heterogeneity among families, we found two loci for PD. Significant evidence for linkage was detected on chromosome 18q11 (maximum lod score [MLOD] = 4.1) and suggestive evidence for linkage was obtained on chromosome 3q25 (MLOD = 2.5). These results were strongest in families not previously screened for linkage, and simulation studies suggest that these findings are likely due to locus heterogeneity rather than random statistical error. The finding of two loci (one highly statistically significant) suggests that additional PD susceptibility genes might be identified through targeted candidate gene studies in these regions.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Am J Hum Genet

DOI

EISSN

1537-6605

Publication Date

April 2009

Volume

84

Issue

4

Start / End Page

499 / 504

Location

United States

Related Subject Headings

  • Statistics, Nonparametric
  • Polymorphism, Single Nucleotide
  • Parkinson Disease
  • Models, Genetic
  • Middle Aged
  • Male
  • Lod Score
  • Humans
  • Genome-Wide Association Study
  • Genetics & Heredity
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gao, X., Martin, E. R., Liu, Y., Mayhew, G., Vance, J. M., & Scott, W. K. (2009). Genome-wide linkage screen in familial Parkinson disease identifies loci on chromosomes 3 and 18. Am J Hum Genet, 84(4), 499–504. https://doi.org/10.1016/j.ajhg.2009.03.005
Gao, Xiaoyi, Eden R. Martin, Yutao Liu, Gregory Mayhew, Jeffery M. Vance, and William K. Scott. “Genome-wide linkage screen in familial Parkinson disease identifies loci on chromosomes 3 and 18.Am J Hum Genet 84, no. 4 (April 2009): 499–504. https://doi.org/10.1016/j.ajhg.2009.03.005.
Gao X, Martin ER, Liu Y, Mayhew G, Vance JM, Scott WK. Genome-wide linkage screen in familial Parkinson disease identifies loci on chromosomes 3 and 18. Am J Hum Genet. 2009 Apr;84(4):499–504.
Gao, Xiaoyi, et al. “Genome-wide linkage screen in familial Parkinson disease identifies loci on chromosomes 3 and 18.Am J Hum Genet, vol. 84, no. 4, Apr. 2009, pp. 499–504. Pubmed, doi:10.1016/j.ajhg.2009.03.005.
Gao X, Martin ER, Liu Y, Mayhew G, Vance JM, Scott WK. Genome-wide linkage screen in familial Parkinson disease identifies loci on chromosomes 3 and 18. Am J Hum Genet. 2009 Apr;84(4):499–504.
Journal cover image

Published In

Am J Hum Genet

DOI

EISSN

1537-6605

Publication Date

April 2009

Volume

84

Issue

4

Start / End Page

499 / 504

Location

United States

Related Subject Headings

  • Statistics, Nonparametric
  • Polymorphism, Single Nucleotide
  • Parkinson Disease
  • Models, Genetic
  • Middle Aged
  • Male
  • Lod Score
  • Humans
  • Genome-Wide Association Study
  • Genetics & Heredity