Acetate metabolism and aging: An emerging connection.

Journal Article (Journal Article)

Sirtuins are NAD(+)-dependent protein deacetylases that regulate gene silencing, energy metabolism and aging from bacteria to mammals. SIRT3, a mammalian mitochondrial sirtuin, deacetylates acetyl-CoA synthetase (AceCS2) in the mitochondria. AceCS2 is conserved from bacteria to humans, catalyzes the conversion of acetate to acetyl-CoA and enables peripheral tissues to utilize acetate during fasting conditions. Here, we review the regulation of acetate metabolism by sirtuins, the remarkable conservation of this metabolic regulatory pathway and its emerging role in the regulation of aging and longevity.

Full Text

Duke Authors

Cited Authors

  • Shimazu, T; Hirschey, MD; Huang, J-Y; Ho, LTY; Verdin, E

Published Date

  • 2010

Published In

Volume / Issue

  • 131 / 7-8

Start / End Page

  • 511 - 516

PubMed ID

  • 20478325

Electronic International Standard Serial Number (EISSN)

  • 1872-6216

Digital Object Identifier (DOI)

  • 10.1016/j.mad.2010.05.001


  • eng

Conference Location

  • Ireland