Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling.


Journal Article (Review)

Sirtuins are a highly conserved family of proteins whose activity can prolong the lifespan of model organisms such as yeast, worms and flies. Mammals contain seven sirtuins (SIRT1-7) that modulate distinct metabolic and stress response pathways. Three sirtuins, SIRT3, SIRT4 and SIRT5, are located in the mitochondria, dynamic organelles that function as the primary site of oxidative metabolism and play crucial roles in apoptosis and intracellular signaling. Recent findings have shed light on how the mitochondrial sirtuins function in the control of basic mitochondrial biology, including energy production, metabolism, apoptosis and intracellular signaling.

Full Text

Duke Authors

Cited Authors

  • Verdin, E; Hirschey, MD; Finley, LWS; Haigis, MC

Published Date

  • December 2010

Published In

Volume / Issue

  • 35 / 12

Start / End Page

  • 669 - 675

PubMed ID

  • 20863707

Pubmed Central ID

  • 20863707

International Standard Serial Number (ISSN)

  • 0968-0004

Digital Object Identifier (DOI)

  • 10.1016/j.tibs.2010.07.003


  • eng

Conference Location

  • England