Copper-mediated amidation of heterocyclic and aromatic C-H bonds.

Journal Article (Journal Article)

A copper-mediated aerobic coupling reaction enables direct amidation of heterocycles or aromatics having weakly acidic C-H bonds with a variety of nitrogen nucleophiles. These reactions provide efficient access to many biologically important skeletons, including ones with the potential to serve as inhibitors of HMTs.

Full Text

Duke Authors

Cited Authors

  • Wang, Q; Schreiber, SL

Published Date

  • November 2009

Published In

Volume / Issue

  • 11 / 22

Start / End Page

  • 5178 - 5180

PubMed ID

  • 19860425

Pubmed Central ID

  • PMC2776381

Electronic International Standard Serial Number (EISSN)

  • 1523-7052

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/ol902079g


  • eng