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Natural fluctuations of hepatitis C viral load in a homogeneous patient population: a prospective study.

Publication ,  Journal Article
Fanning, L; Kenny-Walsh, E; Levis, J; Choudhury, KR; Cannon, B; Sheehan, M; Whelton, M; Shanahan, F
Published in: Hepatology
January 2000

The aim of this study was to determine the variation in hepatitis C viral load over an extended period of patient follow up. Serum samples were collected from 49 female individuals who were identified as having been infected from the same source of hepatitis C-contaminated anti-D immunoglobulin during the period from 1977 (May) to 1978 (November). All patients attended the hepatitis C clinic at Cork University Hospital, Cork, Ireland. The study group was homogeneous with respect to gender, hepatitis C virus (HCV) genotype (1b), and duration of infection. None of the patients had received antiviral therapy at the time of completion of study. Viral load quantifications were assessed using the Roche Monitor (F. Hoffmann-La Roche, Ltd., Basel, Switzerland) assay. The mean age of the study group at time of infection was 30.3 years (SD +/- 6.1) with a range from 18.5 to 43 years. The mean time of follow-up was 4. 1 years (SD +/- 1.0) with a range from 1.2 to 5 years. The mean rate of change of viral load per year was 0.23 log(10) viral copies per mL serum for the study group (SD +/- 0.19) with a range of -0.18 to 0.78 that was significantly different from zero, P < 10(-10). The rate of change of viral load per year was negatively correlated with viral load at first determination, r = -.35, P =.01. Age at infection did not correlate with the slope of change of viral load, P =.10. In conclusion, most women infected with HCV 1b will have an increase in viral load over time but a few patients who acquire infection early in adult life will show a decrease in viral load.

Duke Scholars

Published In

Hepatology

DOI

ISSN

0270-9139

Publication Date

January 2000

Volume

31

Issue

1

Start / End Page

225 / 229

Location

United States

Related Subject Headings

  • Viral Load
  • Time Factors
  • Rho(D) Immune Globulin
  • Prospective Studies
  • Ireland
  • Humans
  • Hepatitis C
  • Gastroenterology & Hepatology
  • Female
  • Drug Contamination
 

Citation

APA
Chicago
ICMJE
MLA
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Fanning, L., Kenny-Walsh, E., Levis, J., Choudhury, K. R., Cannon, B., Sheehan, M., … Shanahan, F. (2000). Natural fluctuations of hepatitis C viral load in a homogeneous patient population: a prospective study. Hepatology, 31(1), 225–229. https://doi.org/10.1002/hep.510310133
Fanning, L., E. Kenny-Walsh, J. Levis, K. R. Choudhury, B. Cannon, M. Sheehan, M. Whelton, and F. Shanahan. “Natural fluctuations of hepatitis C viral load in a homogeneous patient population: a prospective study.Hepatology 31, no. 1 (January 2000): 225–29. https://doi.org/10.1002/hep.510310133.
Fanning L, Kenny-Walsh E, Levis J, Choudhury KR, Cannon B, Sheehan M, et al. Natural fluctuations of hepatitis C viral load in a homogeneous patient population: a prospective study. Hepatology. 2000 Jan;31(1):225–9.
Fanning, L., et al. “Natural fluctuations of hepatitis C viral load in a homogeneous patient population: a prospective study.Hepatology, vol. 31, no. 1, Jan. 2000, pp. 225–29. Pubmed, doi:10.1002/hep.510310133.
Fanning L, Kenny-Walsh E, Levis J, Choudhury KR, Cannon B, Sheehan M, Whelton M, Shanahan F. Natural fluctuations of hepatitis C viral load in a homogeneous patient population: a prospective study. Hepatology. 2000 Jan;31(1):225–229.
Journal cover image

Published In

Hepatology

DOI

ISSN

0270-9139

Publication Date

January 2000

Volume

31

Issue

1

Start / End Page

225 / 229

Location

United States

Related Subject Headings

  • Viral Load
  • Time Factors
  • Rho(D) Immune Globulin
  • Prospective Studies
  • Ireland
  • Humans
  • Hepatitis C
  • Gastroenterology & Hepatology
  • Female
  • Drug Contamination