Factors controlling cardiac neural crest cell migration.


Journal Article (Review)

Cardiac neural crest cells originate as part of the postotic caudal rhombencephalic neural crest stream. Ectomesenchymal cells in this stream migrate to the circumpharyngeal ridge and then into the caudal pharyngeal arches where they condense to form first a sheath and then the smooth muscle tunics of the persisting pharyngeal arch arteries. A subset of the cells continue migrating into the cardiac outflow tract where they will condense to form the aorticopulmonary septum. Cell signaling, extracellular matrix and cell-cell contacts are all critical for the initial migration, pauses, continued migration, and condensation of these cells. This review elucidates what is currently known about these factors.

Full Text

Cited Authors

  • Kirby, ML; Hutson, MR

Published Date

  • October 2010

Published In

Volume / Issue

  • 4 / 4

Start / End Page

  • 609 - 621

PubMed ID

  • 20890117

Pubmed Central ID

  • 20890117

Electronic International Standard Serial Number (EISSN)

  • 1933-6926

International Standard Serial Number (ISSN)

  • 1933-6918

Digital Object Identifier (DOI)

  • 10.4161/cam.4.4.13489


  • eng