Prognostic validation of an algorithm to convert myocardial perfusion SPECT imaging data from a 12-segment model to a 17-segment model.

Journal Article (Journal Article)

BACKGROUND: A 17-segment model has become the standard for interpreting myocardial perfusion single-photon emission computed tomography (SPECT). Methods for converting pre-existing databases from 12-segment models to the 17-segment model are needed for ongoing prognostic studies. METHODS AND RESULTS: To develop the conversion algorithm, 150 consecutive SPECT studies (82 abnormal) were read by both a 12-segment and the standard 17-segment models. Summed stress scores (SSSs) were calculated from a 17-segment model derived from the 12-segment data and compared to those of the standard 17-segment model. The effect of the conversion algorithm on prognostic data derived from the 12-segment model was evaluated in 25,876 patients from the Duke Nuclear Cardiology Database, including a sample of 3,205 patients with known covariates for adjusted analysis. The derived 17-segment SSS from the 12-segment model was highly correlated (R = 0.99) to the SSS from the standard 17-segment model. In both unadjusted and adjusted analysis, there was no difference in the prognostic information. CONCLUSIONS: An algorithm for conversion of 12-segment perfusion scores to 17-segment scores has been developed which is highly correlated to visual interpretation by the 17-segment model with nearly identical prognostic information.

Full Text

Duke Authors

Cited Authors

  • Salerno, M; Elliot, L; Shaw, LK; Piccini, JP; Pagnanelli, R; Borges-Neto, S

Published Date

  • July 2009

Published In

Volume / Issue

  • 16 / 4

Start / End Page

  • 605 - 613

PubMed ID

  • 19495902

Pubmed Central ID

  • PMC2803346

Electronic International Standard Serial Number (EISSN)

  • 1532-6551

Digital Object Identifier (DOI)

  • 10.1007/s12350-009-9103-z


  • eng

Conference Location

  • United States