A user's guide to the encyclopedia of DNA elements (ENCODE).
Published
Journal Article
The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a collective effort to discover and define the functional elements encoded in the human genome, including genes, transcripts, and transcriptional regulatory regions, together with their attendant chromatin states and DNA methylation patterns. In the process, standards to ensure high-quality data have been implemented, and novel algorithms have been developed to facilitate analysis. Data and derived results are made available through a freely accessible database. Here we provide an overview of the project and the resources it is generating and illustrate the application of ENCODE data to interpret the human genome.
Full Text
Duke Authors
Cited Authors
- ENCODE Project Consortium,
Published Date
- April 2011
Published In
Volume / Issue
- 9 / 4
Start / End Page
- e1001046 -
PubMed ID
- 21526222
Pubmed Central ID
- 21526222
Electronic International Standard Serial Number (EISSN)
- 1545-7885
Digital Object Identifier (DOI)
- 10.1371/journal.pbio.1001046
Language
- eng
Conference Location
- United States