A user's guide to the encyclopedia of DNA elements (ENCODE).

Published

Journal Article

The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a collective effort to discover and define the functional elements encoded in the human genome, including genes, transcripts, and transcriptional regulatory regions, together with their attendant chromatin states and DNA methylation patterns. In the process, standards to ensure high-quality data have been implemented, and novel algorithms have been developed to facilitate analysis. Data and derived results are made available through a freely accessible database. Here we provide an overview of the project and the resources it is generating and illustrate the application of ENCODE data to interpret the human genome.

Full Text

Duke Authors

Cited Authors

  • ENCODE Project Consortium,

Published Date

  • April 19, 2011

Published In

Volume / Issue

  • 9 / 4

Start / End Page

  • e1001046 -

PubMed ID

  • 21526222

Pubmed Central ID

  • 21526222

Electronic International Standard Serial Number (EISSN)

  • 1545-7885

International Standard Serial Number (ISSN)

  • 1544-9173

Digital Object Identifier (DOI)

  • 10.1371/journal.pbio.1001046

Language

  • eng