Alternative splicing in multiple sclerosis and other autoimmune diseases.

Journal Article (Journal Article;Review)

Alternative splicing is a general mechanism for regulating gene expression that affects the RNA products of more than 90% of human genes. Not surprisingly, alternative splicing is observed among gene products of metazoan immune systems, which have evolved to efficiently recognize pathogens and discriminate between "self" and "non-self", and thus need to be both diverse and flexible. In this review we focus on the specific interface between alternative splicing and autoimmune diseases, which result from a malfunctioning of the immune system and are characterized by the inappropriate reaction to self-antigens. Despite the widespread recognition of alternative splicing as one of the major regulators of gene expression, the connections between alternative splicing and autoimmunity have not been apparent. We summarize recent findings connecting splicing and autoimmune disease, and attempt to find common patterns of splicing regulation that may advance our understanding of autoimmune diseases and open new avenues for therapy.

Full Text

Duke Authors

Cited Authors

  • Evsyukova, I; Somarelli, JA; Gregory, SG; Garcia-Blanco, MA

Published Date

  • July 2010

Published In

Volume / Issue

  • 7 / 4

Start / End Page

  • 462 - 473

PubMed ID

  • 20639696

Pubmed Central ID

  • PMC3070910

Electronic International Standard Serial Number (EISSN)

  • 1555-8584

Digital Object Identifier (DOI)

  • 10.4161/rna.7.4.12301


  • eng

Conference Location

  • United States