Early-onset degeneration of the intervertebral disc and vertebral end plate in mice deficient in type IX collagen.

Type IX collagen is an important component of the intervertebral disc extracellular matrix. Mutations in type IX collagen are associated with premature disc degeneration in mice and a predisposition to disc disorders in humans. The aim of this study was to assess the prevalence and timeline of intervertebral disc degeneration in mice homozygous for an inactivated Col9a1 gene.

Full Text

Duke Authors

Cited Authors

  • Boyd, LM; Richardson, WJ; Allen, KD; Flahiff, C; Jing, L; Li, Y; Chen, J; Setton, LA

Published Date

  • January 2008

Published In

Volume / Issue

  • 58 / 1

Start / End Page

  • 164 - 171

PubMed ID

  • 18163498

International Standard Serial Number (ISSN)

  • 0004-3591

Digital Object Identifier (DOI)

  • 10.1002/art.23231

Language

  • eng

Citation Source

  • PubMed