Genetic susceptibility variants for chronic lymphocytic leukemia.

Journal Article (Journal Article)

BACKGROUND: There is strong and consistent evidence that a genetic component contributes to the etiology of chronic lymphocytic leukemia (CLL). A recent genome-wide association study of CLL identified seven genetic variants that increased the risk of CLL within a European population. METHODS: We evaluated the association of these variants, or variants in linkage disequilibrium with these variants, with CLL risk in an independent sample of 438 CLL cases and 328 controls. RESULTS: Of these seven single nucleotide polymorphisms (SNP), six had P trend < 0.05 and had estimated odds ratios (OR) that were strikingly comparable to those of the previous study. Associations were seen for rs9378805 [OR, 1.47; 95% confidence intervals (CI), 1.19-1.80; P trend = 0.0003] near IRF4 and rs735665 near GRAMD1B (OR, 1.47; 95% CI, 1.14-1.89; P trend = 0.003). However, no associations (P > 0.05) were found for rs11083846, nor were any found for any SNP in linkage disequilibrium with rs11083846. CONCLUSIONS: Our results confirm the previous findings and further support the role of a genetic basis in the etiology of CLL; however, more research is needed to elucidate the causal SNP(s) and the potential manner in which these SNPs or linked SNPs function in CLL pathogenesis.

Full Text

Duke Authors

Cited Authors

  • Slager, SL; Goldin, LR; Strom, SS; Lanasa, MC; Spector, LG; Rassenti, L; Leis, JF; Camp, NJ; Kay, NE; Vachon, CM; Glenn, M; Weinberg, JB; Rabe, KG; Cunningham, JM; Achenbach, SJ; Hanson, CA; Marti, GE; Call, TG; Caporaso, NE; Cerhan, JR

Published Date

  • April 2010

Published In

Volume / Issue

  • 19 / 4

Start / End Page

  • 1098 - 1102

PubMed ID

  • 20332261

Pubmed Central ID

  • PMC2852480

Electronic International Standard Serial Number (EISSN)

  • 1538-7755

Digital Object Identifier (DOI)

  • 10.1158/1055-9965.EPI-09-1217


  • eng

Conference Location

  • United States