Genetic susceptibility variants for chronic lymphocytic leukemia.


Journal Article

There is strong and consistent evidence that a genetic component contributes to the etiology of chronic lymphocytic leukemia (CLL). A recent genome-wide association study of CLL identified seven genetic variants that increased the risk of CLL within a European population.We evaluated the association of these variants, or variants in linkage disequilibrium with these variants, with CLL risk in an independent sample of 438 CLL cases and 328 controls.Of these seven single nucleotide polymorphisms (SNP), six had P trend < 0.05 and had estimated odds ratios (OR) that were strikingly comparable to those of the previous study. Associations were seen for rs9378805 [OR, 1.47; 95% confidence intervals (CI), 1.19-1.80; P trend = 0.0003] near IRF4 and rs735665 near GRAMD1B (OR, 1.47; 95% CI, 1.14-1.89; P trend = 0.003). However, no associations (P > 0.05) were found for rs11083846, nor were any found for any SNP in linkage disequilibrium with rs11083846.Our results confirm the previous findings and further support the role of a genetic basis in the etiology of CLL; however, more research is needed to elucidate the causal SNP(s) and the potential manner in which these SNPs or linked SNPs function in CLL pathogenesis.

Full Text

Duke Authors

Cited Authors

  • Slager, SL; Goldin, LR; Strom, SS; Lanasa, MC; Spector, LG; Rassenti, L; Leis, JF; Camp, NJ; Kay, NE; Vachon, CM; Glenn, M; Weinberg, JB; Rabe, KG; Cunningham, JM; Achenbach, SJ; Hanson, CA; Marti, GE; Call, TG; Caporaso, NE; Cerhan, JR

Published Date

  • April 2010

Published In

Volume / Issue

  • 19 / 4

Start / End Page

  • 1098 - 1102

PubMed ID

  • 20332261

Pubmed Central ID

  • 20332261

Electronic International Standard Serial Number (EISSN)

  • 1538-7755

International Standard Serial Number (ISSN)

  • 1055-9965

Digital Object Identifier (DOI)

  • 10.1158/1055-9965.EPI-09-1217


  • eng