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Effect of varying injection rates of a saline chaser on aortic enhancement in CT angiography: phantom study.

Publication ,  Journal Article
Schindera, ST; Nelson, RC; Howle, L; Nichols, E; DeLong, DM; Merkle, EM
Published in: Eur Radiol
August 2008

The effect of varying injection rates of a saline chaser on aortic enhancement in computed tomography (CT) angiography was determined. Single-level, dynamic CT images of a physiological flow phantom were acquired between 0 and 50 s after initiation of contrast medium injection. Four injection protocols were applied with identical contrast medium administration (150 ml injected at 5 ml/s). For baseline protocol A, no saline chaser was applied. For protocols B, C, and D, 50 ml of saline was injected at 2.5 ml/s, 5 ml/s, and 10 ml/s, respectively. Injecting the saline chaser at twice the rate as the contrast medium yielded significantly higher peak aortic enhancement values than injecting the saline at half or at the same rate as the contrast medium (P < 0.05). Average peak aortic enhancement (HU) measured 214, 214, 218, and 226 for protocols A, B, C, and D, respectively. The slower the saline-chaser injection rate, the longer the duration of 90% peak enhancement: 13.6, 12.2, and 11.7 s for protocols B, C, and D, respectively (P > 0.05). In CT angiography, saline chaser injected at twice the rate as the contrast medium leads to increased peak aortic enhancement and saline chaser injected at half the rate tends towards prolonging peak aortic enhancement plateau.

Duke Scholars

Published In

Eur Radiol

DOI

ISSN

0938-7994

Publication Date

August 2008

Volume

18

Issue

8

Start / End Page

1683 / 1689

Location

Germany

Related Subject Headings

  • Tomography, X-Ray Computed
  • Sodium Chloride
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Radiographic Image Enhancement
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Iopamidol
  • Humans
  • Drug Administration Schedule
 

Citation

APA
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MLA
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Schindera, S. T., Nelson, R. C., Howle, L., Nichols, E., DeLong, D. M., & Merkle, E. M. (2008). Effect of varying injection rates of a saline chaser on aortic enhancement in CT angiography: phantom study. Eur Radiol, 18(8), 1683–1689. https://doi.org/10.1007/s00330-008-0911-3
Schindera, Sebastian T., Rendon C. Nelson, Laurens Howle, Eli Nichols, David M. DeLong, and Elmar M. Merkle. “Effect of varying injection rates of a saline chaser on aortic enhancement in CT angiography: phantom study.Eur Radiol 18, no. 8 (August 2008): 1683–89. https://doi.org/10.1007/s00330-008-0911-3.
Schindera ST, Nelson RC, Howle L, Nichols E, DeLong DM, Merkle EM. Effect of varying injection rates of a saline chaser on aortic enhancement in CT angiography: phantom study. Eur Radiol. 2008 Aug;18(8):1683–9.
Schindera, Sebastian T., et al. “Effect of varying injection rates of a saline chaser on aortic enhancement in CT angiography: phantom study.Eur Radiol, vol. 18, no. 8, Aug. 2008, pp. 1683–89. Pubmed, doi:10.1007/s00330-008-0911-3.
Schindera ST, Nelson RC, Howle L, Nichols E, DeLong DM, Merkle EM. Effect of varying injection rates of a saline chaser on aortic enhancement in CT angiography: phantom study. Eur Radiol. 2008 Aug;18(8):1683–1689.
Journal cover image

Published In

Eur Radiol

DOI

ISSN

0938-7994

Publication Date

August 2008

Volume

18

Issue

8

Start / End Page

1683 / 1689

Location

Germany

Related Subject Headings

  • Tomography, X-Ray Computed
  • Sodium Chloride
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Radiographic Image Enhancement
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Iopamidol
  • Humans
  • Drug Administration Schedule