Current use for old antibacterial agents: polymyxins, rifamycins, and aminoglycosides.


Journal Article

This article reviews three classes of antibacterial agents that are uncommonly used in bacterial infections and therefore can be thought of as special-use agents. The polymyxins are reserved for gram-negative bacilli that are resistant to virtually all other classes of drugs. Rifampin is used therapeutically, occasionally as a companion drug in treatment of refractory gram-positive coccal infections, especially those involving foreign bodies. Rifaximin is a new rifamycin that is a strict enteric antibiotic approved for treatment of traveler's diarrhea and is showing promise as a possible agent for refractory Clostridium difficile infections. The aminoglycosides are used mainly as companion drugs for the treatment of resistant gram-negative bacillary infections and for gram-positive coccal endocarditis.

Full Text

Cited Authors

  • Chen, LF; Kaye, D

Published Date

  • July 2011

Published In

Volume / Issue

  • 95 / 4

Start / End Page

  • 819 - ix

PubMed ID

  • 21679793

Pubmed Central ID

  • 21679793

Electronic International Standard Serial Number (EISSN)

  • 1557-9859

Digital Object Identifier (DOI)

  • 10.1016/j.mcna.2011.03.007


  • eng

Conference Location

  • United States