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Subcortical lesion severity and orbitofrontal cortex volume in geriatric depression.

Publication ,  Journal Article
Lee, S-H; Payne, ME; Steffens, DC; McQuoid, DR; Lai, T-J; Provenzale, JM; Krishnan, KRR
Published in: Biol Psychiatry
September 1, 2003

Previous studies have shown a reduction of orbital frontal cortex volume and an increase in magnetic resonance imaging signal hyperintensities in geriatric depression. We aimed to assess the relationship between subcortical gray- and deep white-matter lesions and orbital frontal cortex volume in elderly depressives and controls. The study included 41 elderly depressed patients and 41 age-matched control subjects. The orbital frontal cortex volume was measured in both hemispheres using a standardized MRI procedure. Signal hyperintensities were rated on (T2)-weighted MRI with qualitative lesion analyses performed according to an established hyperintensity classification system. After controlling for total cerebral hemisphere, age and sex, the geriatric depressed subjects had significant reduction in orbital frontal cortex volume and compared with the control group. Multiple linear regression modeling indicated that reduced orbital frontal cortex volumes were significantly associated with increased subcortical gray-matter lesions. Our study confirmed the reduction of OFC volume in geriatric depressed subjects. We also suggest that subcortical lesions may decrease OFC volume. Further studies are needed to understand how subcortical lesions may be related to OFC volume changes.

Duke Scholars

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

September 1, 2003

Volume

54

Issue

5

Start / End Page

529 / 533

Location

United States

Related Subject Headings

  • Risk Factors
  • Psychiatry
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Frontal Lobe
  • Female
  • Depressive Disorder, Major
  • Brain
  • Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lee, S.-H., Payne, M. E., Steffens, D. C., McQuoid, D. R., Lai, T.-J., Provenzale, J. M., & Krishnan, K. R. R. (2003). Subcortical lesion severity and orbitofrontal cortex volume in geriatric depression. Biol Psychiatry, 54(5), 529–533. https://doi.org/10.1016/s0006-3223(03)00063-5
Lee, Shwu-Hua, Martha E. Payne, David C. Steffens, Douglas R. McQuoid, Te-Jen Lai, James M. Provenzale, and K Ranga Rama Krishnan. “Subcortical lesion severity and orbitofrontal cortex volume in geriatric depression.Biol Psychiatry 54, no. 5 (September 1, 2003): 529–33. https://doi.org/10.1016/s0006-3223(03)00063-5.
Lee S-H, Payne ME, Steffens DC, McQuoid DR, Lai T-J, Provenzale JM, et al. Subcortical lesion severity and orbitofrontal cortex volume in geriatric depression. Biol Psychiatry. 2003 Sep 1;54(5):529–33.
Lee, Shwu-Hua, et al. “Subcortical lesion severity and orbitofrontal cortex volume in geriatric depression.Biol Psychiatry, vol. 54, no. 5, Sept. 2003, pp. 529–33. Pubmed, doi:10.1016/s0006-3223(03)00063-5.
Lee S-H, Payne ME, Steffens DC, McQuoid DR, Lai T-J, Provenzale JM, Krishnan KRR. Subcortical lesion severity and orbitofrontal cortex volume in geriatric depression. Biol Psychiatry. 2003 Sep 1;54(5):529–533.
Journal cover image

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

September 1, 2003

Volume

54

Issue

5

Start / End Page

529 / 533

Location

United States

Related Subject Headings

  • Risk Factors
  • Psychiatry
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Frontal Lobe
  • Female
  • Depressive Disorder, Major
  • Brain
  • Aged