MRI lesion severity and mortality in geriatric depression.


Journal Article

OBJECTIVE: The authors correlated magnetic resonance imaging (MRI) lesion severity and mortality among depressed elderly patients. METHOD: They examined the association of mortality and deep white-matter hyperintensity (DWMH), periventricular hyperintensity (PVH), and subcortical gray-matter hyperintensity (SGH) ratings in 259 subjects. RESULTS: DWMH and PVH were significantly associated with mortality initially, and, in final modeling, DWMH remained significant. CONCLUSION: These findings suggest that there is a relationship between cerebrovascular disease severity and mortality among depressed patients. More studies, with larger sample sizes, comparing depressed patients and control subjects are needed to further elucidate this relationship.

Full Text

Duke Authors

Cited Authors

  • Levy, RM; Steffens, DC; McQuoid, DR; Provenzale, JM; MacFall, JR; Krishnan, KRR

Published Date

  • November 2003

Published In

Volume / Issue

  • 11 / 6

Start / End Page

  • 678 - 682

PubMed ID

  • 14609809

Pubmed Central ID

  • 14609809

International Standard Serial Number (ISSN)

  • 1064-7481

Digital Object Identifier (DOI)

  • 10.1176/appi.ajgp.11.6.678


  • eng

Conference Location

  • England