Optimization of perfusion imaging for acute cerebral ischemia: review of recent clinical trials and recommendations for future studies.

OBJECTIVE: The use of thrombolytic agents and other forms of reperfusion therapy has provided a means to reverse ischemia and minimize the size of infarctions. The purpose of this review is to examine various clinical trials of reperfusion agents and address key imaging issues. CONCLUSION: Advanced MRI and CT play a growing role in selection of patients for therapy. Numerous clinical trials have shed light on the efficacy of various reperfusion therapies; disparities in trial design have also left unanswered questions.

Duke Scholars

Author James Michael Provenzale Radiology, Neuroradiology