Optimization of perfusion imaging for acute cerebral ischemia: review of recent clinical trials and recommendations for future studies.


Journal Article (Review)

OBJECTIVE: The use of thrombolytic agents and other forms of reperfusion therapy has provided a means to reverse ischemia and minimize the size of infarctions. The purpose of this review is to examine various clinical trials of reperfusion agents and address key imaging issues. CONCLUSION: Advanced MRI and CT play a growing role in selection of patients for therapy. Numerous clinical trials have shed light on the efficacy of various reperfusion therapies; disparities in trial design have also left unanswered questions.

Full Text

Duke Authors

Cited Authors

  • Provenzale, JM; Wintermark, M

Published Date

  • October 2008

Published In

Volume / Issue

  • 191 / 4

Start / End Page

  • 1263 - 1270

PubMed ID

  • 18806174

Pubmed Central ID

  • 18806174

Electronic International Standard Serial Number (EISSN)

  • 1546-3141

Digital Object Identifier (DOI)

  • 10.2214/AJR.07.3575


  • eng

Conference Location

  • United States