A laboratory school comparison of mixed amphetamine salts extended release (Adderall XR) and atomoxetine (Strattera) in school-aged children with attention deficit/hyperactivity disorder.


Journal Article

Mixed amphetamine salts extended release (MAS XR; Adderall XR) and atomoxetine (Strattera) were compared in children 6 to 12 years old with attention deficit/hyperactivity disorder (ADHD) combined or hyperactive/impulsive type in a randomized, double-blind, multicenter, parallel-group, forced-dose-escalation laboratory school study. Primary efficacy measure was the SKAMP (Swanson, Kotkin, Agler, M-Flynn, and Pelham) behavioral rating scale. Changes in mean SKAMP deportment scores from baseline were significantly greater for MAS XR (n = 102) than for atomoxetine (n = 101) overall (-0.56 and -0.13, respectively; p < .0001) and at each week (p < .001). Adverse events were similar for both treatment groups. The extended time course of action and greater therapeutic efficacy of MAS XR suggests that it is more effective than atomoxetine in children with ADHD.

Full Text

Duke Authors

Cited Authors

  • Wigal, SB; McGough, JJ; McCracken, JT; Biederman, J; Spencer, TJ; Posner, KL; Wigal, TL; Kollins, SH; Clark, TM; Mays, DA; Zhang, Y; Tulloch, SJ

Published Date

  • August 2005

Published In

Volume / Issue

  • 9 / 1

Start / End Page

  • 275 - 289

PubMed ID

  • 16371674

Pubmed Central ID

  • 16371674

International Standard Serial Number (ISSN)

  • 1087-0547

Digital Object Identifier (DOI)

  • 10.1177/1087054705281121


  • eng

Conference Location

  • United States