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Effectiveness of methylphenidate in the 10-month continuation phase of the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS).

Publication ,  Journal Article
Vitiello, B; Abikoff, HB; Chuang, SZ; Kollins, SH; McCracken, JT; Riddle, MA; Swanson, JM; Wigal, T; McGough, JJ; Ghuman, JK; Wigal, SB ...
Published in: J Child Adolesc Psychopharmacol
October 2007

OBJECTIVE: The aim of this study was to examine immediate-release methylphenidate effectiveness during the 10-month open-label continuation phase of the Preschoolers with Attention-Deficit/Hyperactivity Disorder (ADHD) Treatment Study (PATS). METHODS: One hundred and forty preschoolers with ADHD, who had improved with acute immediate-release methylphenidate (IR-MPH) treatment, entered a 10-month, open-label medication maintenance at six sites. Assessments included the Clinical Global Impression-Severity (CGI-S), CGI-Improvement (CGI-I), Children's Global Assessment Scale (C-GAS), Swanson, Nolan, and Pelham Questionnaire (SNAP), Scale Strengths and Weaknesses of ADHD-Symptoms and Normal Behaviors (SWAN), Social Competence Scale, Social Skills Rating System (SSRS), and Parenting Stress Index-Short Form (PSI-SF). RESULTS: For the 95 children who completed the 10-month treatment, improvement occurred on the CGI-S (p = 0.02), CGI-I (p < 0.01), C-GAS (p = 0.001), and SSRS (p = 0.01). SNAP and SWAN scores remained stable. Forty five children discontinued: 7 for adverse effects, 7 for behavior worsening, 7 for switching to long-acting stimulants, 3 for inadequate benefit, and 21 for other reasons. The mean MPH dose increased from 14.04 mg/day +/- SD 7.57 (0.71 +/- 0.38 mg/kg per day) at month 1 to 19.98 mg/day +/- 9.56 (0.92 +/- 0.40 mg/kg per day) at month 10. CONCLUSIONS: With careful monitoring and gradual medication dose increase, most preschoolers with ADHD maintained improvement during long-term IR-MPH treatment. There was substantial variability in effective and tolerated dosing.

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Published In

J Child Adolesc Psychopharmacol

DOI

ISSN

1044-5463

Publication Date

October 2007

Volume

17

Issue

5

Start / End Page

593 / 604

Location

United States

Related Subject Headings

  • Stress, Psychological
  • Socioeconomic Factors
  • Psychiatric Status Rating Scales
  • Patient Dropouts
  • Parents
  • Neuropsychological Tests
  • Methylphenidate
  • Male
  • Humans
  • Female
 

Citation

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Vitiello, B., Abikoff, H. B., Chuang, S. Z., Kollins, S. H., McCracken, J. T., Riddle, M. A., … Greenhill, L. L. (2007). Effectiveness of methylphenidate in the 10-month continuation phase of the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS). J Child Adolesc Psychopharmacol, 17(5), 593–604. https://doi.org/10.1089/cap.2007.0058
Vitiello, Benedetto, Howard B. Abikoff, Shirley Z. Chuang, Scott H. Kollins, James T. McCracken, Mark A. Riddle, James M. Swanson, et al. “Effectiveness of methylphenidate in the 10-month continuation phase of the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS).J Child Adolesc Psychopharmacol 17, no. 5 (October 2007): 593–604. https://doi.org/10.1089/cap.2007.0058.
Vitiello B, Abikoff HB, Chuang SZ, Kollins SH, McCracken JT, Riddle MA, et al. Effectiveness of methylphenidate in the 10-month continuation phase of the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS). J Child Adolesc Psychopharmacol. 2007 Oct;17(5):593–604.
Vitiello, Benedetto, et al. “Effectiveness of methylphenidate in the 10-month continuation phase of the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS).J Child Adolesc Psychopharmacol, vol. 17, no. 5, Oct. 2007, pp. 593–604. Pubmed, doi:10.1089/cap.2007.0058.
Vitiello B, Abikoff HB, Chuang SZ, Kollins SH, McCracken JT, Riddle MA, Swanson JM, Wigal T, McGough JJ, Ghuman JK, Wigal SB, Skrobala AM, Davies M, Posner K, Cunningham C, Greenhill LL. Effectiveness of methylphenidate in the 10-month continuation phase of the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS). J Child Adolesc Psychopharmacol. 2007 Oct;17(5):593–604.
Journal cover image

Published In

J Child Adolesc Psychopharmacol

DOI

ISSN

1044-5463

Publication Date

October 2007

Volume

17

Issue

5

Start / End Page

593 / 604

Location

United States

Related Subject Headings

  • Stress, Psychological
  • Socioeconomic Factors
  • Psychiatric Status Rating Scales
  • Patient Dropouts
  • Parents
  • Neuropsychological Tests
  • Methylphenidate
  • Male
  • Humans
  • Female