Alpha-2 adrenergic receptors and attention-deficit/hyperactivity disorder.


Journal Article (Review)

Pharmacologic management of attention-deficit/hyperactivity disorder (ADHD) has expanded beyond stimulant medications to include alpha-2 adrenergic agonists. These agents exert their actions through presynaptic stimulation and likely involve facilitation of dopamine and noradrenaline neurotransmission, both of which are thought to play critical roles in the pathophysiology of ADHD. Furthermore, frontostriatal dysfunction giving rise to neuropsychological weaknesses has been well-established in patients with ADHD and may explain how alpha-2 agents exert their beneficial effects. In the following review, we consider relevant neurobiological underpinnings of ADHD with respect to why alpha-2 agents may be effective in treating this condition. We also review new formulations of alpha-2 agonists, emerging data on their use in ADHD, and implications for clinical practice. Integrating knowledge of pathophysiologic mechanisms and mechanisms of drug action may inform our medication choices and facilitate treatment of ADHD and related disorders.

Full Text

Duke Authors

Cited Authors

  • Cinnamon Bidwell, L; Dew, RE; Kollins, SH

Published Date

  • October 2010

Published In

Volume / Issue

  • 12 / 5

Start / End Page

  • 366 - 373

PubMed ID

  • 20652773

Pubmed Central ID

  • 20652773

Electronic International Standard Serial Number (EISSN)

  • 1535-1645

Digital Object Identifier (DOI)

  • 10.1007/s11920-010-0136-4


  • eng

Conference Location

  • United States