Is there a best way to set positive expiratory-end pressure for mechanical ventilatory support in acute lung injury?

Journal Article (Journal Article;Review)

Airspace collapse is a hallmark of parenchymal lung injury. Strategies to reopen and maintain patency of these regions offer three advantages: improved gas exchange, less lung injury, and improved lung compliance. Elevations in intrathoracic pressure to achieve these goals, however, may overdistend healthier lung regions and compromise cardiac function. Positive expiratory-end pressure is a widely used technique to maintain alveolar patency, but its beneficial effects must be balanced against its harmful effects.

Full Text

Duke Authors

Cited Authors

  • MacIntyre, NR

Published Date

  • June 2008

Published In

Volume / Issue

  • 29 / 2

Start / End Page

  • 233 - v

PubMed ID

  • 18440433

Pubmed Central ID

  • 18440433

International Standard Serial Number (ISSN)

  • 0272-5231

Digital Object Identifier (DOI)

  • 10.1016/j.ccm.2008.01.005


  • eng

Conference Location

  • United States