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Chronic obstructive pulmonary disease: emerging medical therapies.

Publication ,  Journal Article
MacIntyre, NR
Published in: Respir Care
January 2004

As many as 10 million Americans have chronic obstructive pulmonary disease and as a consequence experience disabling symptoms, high cost of care, and substantial mortality. Several new approaches are being investigated for possible benefit in managing (or even reversing) chronic obstructive pulmonary disease. This article reviews 4 new approaches that are either in or close to phase III trials: long-acting bronchodilators, phosphodiesterase-4 inhibitors, vasodilators, and retinoids. Of those tiotropium appears to be the closest to receiving clinical approval in the United States. The risk/benefit ratio and the cost-effectiveness of the other compounds are less clear and await additional study.

Duke Scholars

Published In

Respir Care

ISSN

0020-1324

Publication Date

January 2004

Volume

49

Issue

1

Start / End Page

64 / 69

Location

United States

Related Subject Headings

  • Vasodilator Agents
  • Respiratory System
  • Quality of Life
  • Pulmonary Emphysema
  • Pulmonary Disease, Chronic Obstructive
  • Pulmonary Alveoli
  • Phosphodiesterase Inhibitors
  • Humans
  • Bronchodilator Agents
  • Animals
 

Citation

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ICMJE
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MacIntyre, N. R. (2004). Chronic obstructive pulmonary disease: emerging medical therapies. Respir Care, 49(1), 64–69.
MacIntyre, Neil R. “Chronic obstructive pulmonary disease: emerging medical therapies.Respir Care 49, no. 1 (January 2004): 64–69.
MacIntyre NR. Chronic obstructive pulmonary disease: emerging medical therapies. Respir Care. 2004 Jan;49(1):64–9.
MacIntyre, Neil R. “Chronic obstructive pulmonary disease: emerging medical therapies.Respir Care, vol. 49, no. 1, Jan. 2004, pp. 64–69.
MacIntyre NR. Chronic obstructive pulmonary disease: emerging medical therapies. Respir Care. 2004 Jan;49(1):64–69.

Published In

Respir Care

ISSN

0020-1324

Publication Date

January 2004

Volume

49

Issue

1

Start / End Page

64 / 69

Location

United States

Related Subject Headings

  • Vasodilator Agents
  • Respiratory System
  • Quality of Life
  • Pulmonary Emphysema
  • Pulmonary Disease, Chronic Obstructive
  • Pulmonary Alveoli
  • Phosphodiesterase Inhibitors
  • Humans
  • Bronchodilator Agents
  • Animals