The "best" tidal volume for managing acute lung injury/acute respiratory distress syndrome.
Publication
, Journal Article
MacIntyre, NR
Published in: Respir Care Clin N Am
September 2004
An inappropriate tidal volume setting can overstretch and injure the lung. Maximal stretch, tidal stretch, frequency of stretch, and rate of stretch are all implicated in such injury. Moreover, the stretch injury produces systemic injury by liberating cytokines and translocating bacteria in the lung. Clinical trials have shown that limiting maximal and tidal stretch improves outcomes, even if gas exchange is partially compromised. Current strategies should focus on limiting tidal and maximal stretch as much as possible.
Duke Scholars
Published In
Respir Care Clin N Am
DOI
ISSN
1078-5337
Publication Date
September 2004
Volume
10
Issue
3
Start / End Page
309 / v
Location
United States
Related Subject Headings
- Tidal Volume
- Respiratory System
- Respiratory Distress Syndrome
- Randomized Controlled Trials as Topic
- Pulmonary Gas Exchange
- Positive-Pressure Respiration
- Humans
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
MacIntyre, N. R. (2004). The "best" tidal volume for managing acute lung injury/acute respiratory distress syndrome. Respir Care Clin N Am, 10(3), 309–v. https://doi.org/10.1016/j.rcc.2004.04.007
MacIntyre, Neil R. “The "best" tidal volume for managing acute lung injury/acute respiratory distress syndrome.” Respir Care Clin N Am 10, no. 3 (September 2004): 309–v. https://doi.org/10.1016/j.rcc.2004.04.007.
MacIntyre NR. The "best" tidal volume for managing acute lung injury/acute respiratory distress syndrome. Respir Care Clin N Am. 2004 Sep;10(3):309–v.
MacIntyre, Neil R. “The "best" tidal volume for managing acute lung injury/acute respiratory distress syndrome.” Respir Care Clin N Am, vol. 10, no. 3, Sept. 2004, pp. 309–v. Pubmed, doi:10.1016/j.rcc.2004.04.007.
MacIntyre NR. The "best" tidal volume for managing acute lung injury/acute respiratory distress syndrome. Respir Care Clin N Am. 2004 Sep;10(3):309–v.
Published In
Respir Care Clin N Am
DOI
ISSN
1078-5337
Publication Date
September 2004
Volume
10
Issue
3
Start / End Page
309 / v
Location
United States
Related Subject Headings
- Tidal Volume
- Respiratory System
- Respiratory Distress Syndrome
- Randomized Controlled Trials as Topic
- Pulmonary Gas Exchange
- Positive-Pressure Respiration
- Humans
- Animals