The "best" tidal volume for managing acute lung injury/acute respiratory distress syndrome.

Journal Article (Journal Article;Review)

An inappropriate tidal volume setting can overstretch and injure the lung. Maximal stretch, tidal stretch, frequency of stretch, and rate of stretch are all implicated in such injury. Moreover, the stretch injury produces systemic injury by liberating cytokines and translocating bacteria in the lung. Clinical trials have shown that limiting maximal and tidal stretch improves outcomes, even if gas exchange is partially compromised. Current strategies should focus on limiting tidal and maximal stretch as much as possible.

Full Text

Duke Authors

Cited Authors

  • MacIntyre, NR

Published Date

  • September 2004

Published In

Volume / Issue

  • 10 / 3

Start / End Page

  • 309 - v

PubMed ID

  • 15458729

International Standard Serial Number (ISSN)

  • 1078-5337

Digital Object Identifier (DOI)

  • 10.1016/j.rcc.2004.04.007


  • eng

Conference Location

  • United States