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The "best" tidal volume for managing acute lung injury/acute respiratory distress syndrome.

Publication ,  Journal Article
MacIntyre, NR
Published in: Respir Care Clin N Am
September 2004

An inappropriate tidal volume setting can overstretch and injure the lung. Maximal stretch, tidal stretch, frequency of stretch, and rate of stretch are all implicated in such injury. Moreover, the stretch injury produces systemic injury by liberating cytokines and translocating bacteria in the lung. Clinical trials have shown that limiting maximal and tidal stretch improves outcomes, even if gas exchange is partially compromised. Current strategies should focus on limiting tidal and maximal stretch as much as possible.

Duke Scholars

Published In

Respir Care Clin N Am

DOI

ISSN

1078-5337

Publication Date

September 2004

Volume

10

Issue

3

Start / End Page

309 / v

Location

United States

Related Subject Headings

  • Tidal Volume
  • Respiratory System
  • Respiratory Distress Syndrome
  • Randomized Controlled Trials as Topic
  • Pulmonary Gas Exchange
  • Positive-Pressure Respiration
  • Humans
  • Animals
 

Citation

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ICMJE
MLA
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MacIntyre, N. R. (2004). The "best" tidal volume for managing acute lung injury/acute respiratory distress syndrome. Respir Care Clin N Am, 10(3), 309–v. https://doi.org/10.1016/j.rcc.2004.04.007
MacIntyre, Neil R. “The "best" tidal volume for managing acute lung injury/acute respiratory distress syndrome.Respir Care Clin N Am 10, no. 3 (September 2004): 309–v. https://doi.org/10.1016/j.rcc.2004.04.007.
MacIntyre NR. The "best" tidal volume for managing acute lung injury/acute respiratory distress syndrome. Respir Care Clin N Am. 2004 Sep;10(3):309–v.
MacIntyre, Neil R. “The "best" tidal volume for managing acute lung injury/acute respiratory distress syndrome.Respir Care Clin N Am, vol. 10, no. 3, Sept. 2004, pp. 309–v. Pubmed, doi:10.1016/j.rcc.2004.04.007.
MacIntyre NR. The "best" tidal volume for managing acute lung injury/acute respiratory distress syndrome. Respir Care Clin N Am. 2004 Sep;10(3):309–v.
Journal cover image

Published In

Respir Care Clin N Am

DOI

ISSN

1078-5337

Publication Date

September 2004

Volume

10

Issue

3

Start / End Page

309 / v

Location

United States

Related Subject Headings

  • Tidal Volume
  • Respiratory System
  • Respiratory Distress Syndrome
  • Randomized Controlled Trials as Topic
  • Pulmonary Gas Exchange
  • Positive-Pressure Respiration
  • Humans
  • Animals