Mechanical ventilation strategies for lung protection.


Journal Article

A large body of animal literature has shown that lungs stretched beyond their normal maximum are likely to be injured and release inflammatory cytokines into the systemic circulation. Moreover, this injury seems to be compounded if alveolar collapse also occurs. This has give rise to the notion that adequate positive end expiratory pressure (PEEP) to prevent derecruitment coupled with a tidal volume-PEEP combination that limits maximal distention to below the normal maximum is the ideal way to provide positive pressure ventilatory support. Some have argued that static pressure-volume plots to describe upper and lower inflection points are particularly important in implementing this approach. Supporting this concept is the recently completed NIH trial showing improved survival in acute respiratory distress syndrome (ARDS) when a small tidal volume strategy was used.

Full Text

Duke Authors

Cited Authors

  • MacIntyre, NR

Published Date

  • 2000

Published In

Volume / Issue

  • 21 / 3

Start / End Page

  • 215 - 222

PubMed ID

  • 16088734

Pubmed Central ID

  • 16088734

International Standard Serial Number (ISSN)

  • 1069-3424

Digital Object Identifier (DOI)

  • 10.1055/s-2000-9850


  • eng

Conference Location

  • United States