Aerosol characteristics of 99mTc-pentetic acid (DTPA) and synthetic surfactant (Exosurf).
Journal Article (Journal Article)
This study evaluated the feasibility of using 99mTc-pentetic acid (DTPA) as a radioactive tracer for aerosolized synthetic surfactant (DPPC, cetyl alcohol, tyloxapol). The 99mTc-DTPA was admixed with surfactant and aerosolized using a nebulizer system interfaced to a ventilator with a cascade impactor attached to the endotracheal tube. Particle size distribution for DPPC, cetyl alcohol, and 99mTc-DTPA were almost identical during the 0- to 15-, 15- to 30-, and 0- to 30-min collection periods. Tyloxapol exhibited a unique distribution pattern with increased deposition in large (> 10 microns) and small (0.65 to 1.1 microns) particles. The mass median aerodynamic diameter for all aerosolized components was in the respirable range of 2.1 to 2.5 microns. A mixture of 99mTc-DTPA with synthetic surfactant appears to be a reasonable method to evaluate surfactant deposition.
Full Text
Duke Authors
Cited Authors
- Coleman, RE; MacIntyre, N; Snyder, G; Pattishall, E; Zaccardelli, D
Published Date
- June 1, 1994
Published In
Volume / Issue
- 105 / 6
Start / End Page
- 1765 - 1769
PubMed ID
- 8205874
Pubmed Central ID
- 8205874
International Standard Serial Number (ISSN)
- 0012-3692
Digital Object Identifier (DOI)
- 10.1378/chest.105.6.1765
Language
- eng
Conference Location
- United States