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Intrabreath analysis of carbon monoxide uptake during exercise in patients at risk for lung injury.

Publication ,  Journal Article
Huang, Y-CT; O'brien, SR; Vredenburgh, J; Folz, RJ; Macintyre, NR
Published in: Respir Med
July 2006

The single exhalation analysis of carbon monoxide, acetylene, and methane allows the determination of intrabreath (regional) DL, pulmonary capillary blood flow and ventilation inhomogeneities during rest and exercise. We reasoned that this technique might be more sensitive in detecting regional pulmonary capillary abnormalities than resting single breath DL (DL(sb)). We selected a group of breast cancer patients in high-dose chemotherapy (HDCT) protocols who were at risk for pulmonary injury. We grouped the patients into pre-HDCT and post-HDCT, and used resting DL(sb) to further categorize the latter into those with and without pulmonary injury. We found that exercise DL increases were blunted in post-HDCT patients with low resting DL(sb). More importantly, even in post-HDCT patients with normal resting DL(sb), exercise DL response was reduced in the slowest emptying lung units along with evidence for ventilation inhomogeneities (increased methane slope). We conclude that exercise assessments of DL at low lung volumes and gas mixing properties may be sensitive indicators of lung injury.

Duke Scholars

Published In

Respir Med

DOI

ISSN

0954-6111

Publication Date

July 2006

Volume

100

Issue

7

Start / End Page

1226 / 1233

Location

England

Related Subject Headings

  • Respiratory System
  • Pulmonary Diffusing Capacity
  • Pulmonary Circulation
  • Oxygen
  • Middle Aged
  • Lung Diseases
  • Humans
  • Heart Rate
  • Female
  • Exercise Test
 

Citation

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Huang, Y.-C., O’brien, S. R., Vredenburgh, J., Folz, R. J., & Macintyre, N. R. (2006). Intrabreath analysis of carbon monoxide uptake during exercise in patients at risk for lung injury. Respir Med, 100(7), 1226–1233. https://doi.org/10.1016/j.rmed.2005.10.018
Huang, Yuh-Chin T., Sharon R. O’brien, James Vredenburgh, Rodney J. Folz, and Neil R. Macintyre. “Intrabreath analysis of carbon monoxide uptake during exercise in patients at risk for lung injury.Respir Med 100, no. 7 (July 2006): 1226–33. https://doi.org/10.1016/j.rmed.2005.10.018.
Huang Y-CT, O’brien SR, Vredenburgh J, Folz RJ, Macintyre NR. Intrabreath analysis of carbon monoxide uptake during exercise in patients at risk for lung injury. Respir Med. 2006 Jul;100(7):1226–33.
Huang, Yuh-Chin T., et al. “Intrabreath analysis of carbon monoxide uptake during exercise in patients at risk for lung injury.Respir Med, vol. 100, no. 7, July 2006, pp. 1226–33. Pubmed, doi:10.1016/j.rmed.2005.10.018.
Huang Y-CT, O’brien SR, Vredenburgh J, Folz RJ, Macintyre NR. Intrabreath analysis of carbon monoxide uptake during exercise in patients at risk for lung injury. Respir Med. 2006 Jul;100(7):1226–1233.
Journal cover image

Published In

Respir Med

DOI

ISSN

0954-6111

Publication Date

July 2006

Volume

100

Issue

7

Start / End Page

1226 / 1233

Location

England

Related Subject Headings

  • Respiratory System
  • Pulmonary Diffusing Capacity
  • Pulmonary Circulation
  • Oxygen
  • Middle Aged
  • Lung Diseases
  • Humans
  • Heart Rate
  • Female
  • Exercise Test