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Current issues in mechanical ventilation for respiratory failure.

Publication ,  Journal Article
MacIntyre, NR
Published in: Chest
November 2005

The morbidity and mortality associated with respiratory failure is, to a certain extent, iatrogenic. Mechanical ventilation, although the mainstay of treatment for respiratory distress syndrome, can result in physical trauma to lung tissue (ventilator-induced lung injury [VILI]). Strategies to alleviate VILI are often termed lung-protective strategies and are aimed at reducing overstretching and shear stresses associated with repetitive alveolar collapse and reopening. Lower tidal volumes during ventilation, maintenance of positive-end expiratory pressure, and high-frequency ventilation are the best-studied lung-protective strategies that appear to reduce VILI. Faster withdrawal from mechanical ventilation could also improve outcomes and lower the costs associated with care. To enhance the success of weaning from mechanical ventilation, the cooperative efforts of physicians and respiratory therapists are needed. These efforts involve the initiation of spontaneous-breathing trials, implementation of systematic weaning protocols, and optimization of individual patient interventions.

Duke Scholars

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Published In

Chest

DOI

ISSN

0012-3692

Publication Date

November 2005

Volume

128

Issue

5 Suppl 2

Start / End Page

561S / 567S

Location

United States

Related Subject Headings

  • Ventilator Weaning
  • Tidal Volume
  • Respiratory System
  • Respiratory Insufficiency
  • Respiratory Distress Syndrome
  • Respiration, Artificial
  • Pulmonary Alveoli
  • Positive-Pressure Respiration
  • Humans
  • Animals
 

Citation

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MacIntyre, N. R. (2005). Current issues in mechanical ventilation for respiratory failure. Chest, 128(5 Suppl 2), 561S-567S. https://doi.org/10.1378/chest.128.5_suppl_2.561S
MacIntyre, Neil R. “Current issues in mechanical ventilation for respiratory failure.Chest 128, no. 5 Suppl 2 (November 2005): 561S-567S. https://doi.org/10.1378/chest.128.5_suppl_2.561S.
MacIntyre NR. Current issues in mechanical ventilation for respiratory failure. Chest. 2005 Nov;128(5 Suppl 2):561S-567S.
MacIntyre, Neil R. “Current issues in mechanical ventilation for respiratory failure.Chest, vol. 128, no. 5 Suppl 2, Nov. 2005, pp. 561S-567S. Pubmed, doi:10.1378/chest.128.5_suppl_2.561S.
MacIntyre NR. Current issues in mechanical ventilation for respiratory failure. Chest. 2005 Nov;128(5 Suppl 2):561S-567S.
Journal cover image

Published In

Chest

DOI

ISSN

0012-3692

Publication Date

November 2005

Volume

128

Issue

5 Suppl 2

Start / End Page

561S / 567S

Location

United States

Related Subject Headings

  • Ventilator Weaning
  • Tidal Volume
  • Respiratory System
  • Respiratory Insufficiency
  • Respiratory Distress Syndrome
  • Respiration, Artificial
  • Pulmonary Alveoli
  • Positive-Pressure Respiration
  • Humans
  • Animals