Sleep quality varies as a function of 5-HTTLPR genotype and stress.

Journal Article (Journal Article)

OBJECTIVE: To test the hypothesis that allelic variation in 5HTT gene-linked polymorphic region (5-HTTLPR) genotype was associated with sleep quality (Pittsburgh Sleep Quality Index, PSQI) as a main effect and as moderated by the chronic stress of caregiving. Serotonin (5HT) is involved in sleep regulation and the 5HT transporter (5HTT) regulates 5HT function. A common 44-base pair deletion (s allele) polymorphism in the 5-HTTLPR is associated with reduced 5HTT transcription efficiency and 5HT uptake in vitro. METHODS: Subjects were 142 adult primary caregivers for a spouse or parent with dementia and 146 noncaregiver controls. Subjects underwent genotyping and completed the PSQI. RESULTS: Variation in 5-HTTLPR genotype was not related to sleep quality as a main effect (p > .36). However, there was a caregiver X 5-HTTLPR interaction (p < .009), such that the s allele was associated with poorer sleep quality in caregivers as compared with controls. CONCLUSIONS: Findings suggest that the s allele may moderate sleep disturbance in response to chronic stress.

Full Text

Duke Authors

Cited Authors

  • Brummett, BH; Krystal, AD; Ashley-Koch, A; Kuhn, CM; Züchner, S; Siegler, IC; Barefoot, JC; Ballard, EL; Gwyther, LP; Williams, RB

Published Date

  • September 2007

Published In

Volume / Issue

  • 69 / 7

Start / End Page

  • 621 - 624

PubMed ID

  • 17766685

Pubmed Central ID

  • PMC2758820

Electronic International Standard Serial Number (EISSN)

  • 1534-7796

Digital Object Identifier (DOI)

  • 10.1097/PSY.0b013e31814b8de6


  • eng

Conference Location

  • United States