Transdermal nicotine attenuates depression symptoms in nonsmokers: a double-blind, placebo-controlled trial.


Journal Article

Despite established links between nicotine dependence and depression, little research has examined the effects of nicotine on depression symptoms.This study evaluated the acute and chronic effects of transdermal nicotine in nonsmokers with baseline depression symptoms during a 4-week, double-blind, placebo-controlled trial.Nonsmokers with scores >or=10 on the Center for Epidemiological Studies Depression scale (CES-D) were recruited from the community. Mood and cognitive performance were measured at baseline (day 0) and at 1, 8, 21, and 28 days. Participants were randomly assigned to wear a placebo or nicotine patch for 4 weeks (3.5 mg/day during weeks 1 and 4; 7 mg/day during weeks 2 and 3). The final sample consisted of 11 nonsmokers with a mean baseline CES-D score of 27.36 (SD=10.53).Salivary nicotine levels indicated the majority of participants were compliant with treatment. Acute nicotine did not alter mood. After adjusting for baseline values, chronic nicotine resulted in a significant decline in CES-D scores at day 8 (3.5 mg/day), but returned to placebo levels by the last visit. This return to baseline levels was coincident with a decrease in nicotine administration from 7 to 3.5 mg/day. A similar trend for improved response inhibition as measured by the Conners Continuous Performance Task was also observed. Reported side effects were infrequent and minimal.These findings suggest a role for nicotinic receptor systems in the pathophysiology of depression and that nicotinic compounds should be evaluated for treating depression symptoms.

Full Text

Duke Authors

Cited Authors

  • McClernon, FJ; Hiott, FB; Westman, EC; Rose, JE; Levin, ED

Published Date

  • November 2006

Published In

Volume / Issue

  • 189 / 1

Start / End Page

  • 125 - 133

PubMed ID

  • 16977477

Pubmed Central ID

  • 16977477

Electronic International Standard Serial Number (EISSN)

  • 1432-2072

International Standard Serial Number (ISSN)

  • 0033-3158

Digital Object Identifier (DOI)

  • 10.1007/s00213-006-0516-y


  • eng