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Individual differences in nicotine dependence, withdrawal symptoms, and sex predict transient fMRI-BOLD responses to smoking cues.

Publication ,  Journal Article
McClernon, FJ; Kozink, RV; Rose, JE
Published in: Neuropsychopharmacology
August 2008

Exposure to smoking cues increases craving for cigarettes and can precipitate relapse. Whereas brain imaging studies have identified a distinct network of brain regions subserving the processing of smoking cues, little is known about the influence of individual difference factors and withdrawal symptoms on brain cue reactivity. Multiple regression analysis was used to evaluate relations between individual difference factors and withdrawal symptoms and event-related blood oxygen level-dependent responses to visual smoking cues in a sample of 30 smokers. Predictors were self-report nicotine dependence (Fagerström test of nicotine dependence, FTND), prescan withdrawal symptoms (craving and negative affect), and sex. The unique variance of each predictor was examined after controlling for each of the others. Positive associations were observed between FTND and reactivity to cues in right anterior cingulate and orbitofrontal cortex (OFC) whereas negative associations were observed between prescan craving and reactivity in ventral striatum. Higher negative affect or being male was associated with greater reactivity in left hippocampus and left OFC. Women exhibited greater cue reactivity than men in regions including the cuneus and left superior temporal gyrus. Individual difference factors and withdrawal symptoms were uniquely associated with brain reactivity to smoking cues in regions subserving reward, affect, attention, motivation, and memory. These findings provide further evidence that reactivity to conditioned drug cues is multiply determined and suggest that smoking cessation treatments designed to reduce cue reactivity focus on each of these variables.

Duke Scholars

Published In

Neuropsychopharmacology

DOI

ISSN

0893-133X

Publication Date

August 2008

Volume

33

Issue

9

Start / End Page

2148 / 2157

Location

England

Related Subject Headings

  • Tobacco Use Disorder
  • Surveys and Questionnaires
  • Smoking
  • Sex Characteristics
  • Psychiatry
  • Oxygen
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Individuality
 

Citation

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McClernon, F. J., Kozink, R. V., & Rose, J. E. (2008). Individual differences in nicotine dependence, withdrawal symptoms, and sex predict transient fMRI-BOLD responses to smoking cues. Neuropsychopharmacology, 33(9), 2148–2157. https://doi.org/10.1038/sj.npp.1301618
McClernon, Francis J., Rachel V. Kozink, and Jed E. Rose. “Individual differences in nicotine dependence, withdrawal symptoms, and sex predict transient fMRI-BOLD responses to smoking cues.Neuropsychopharmacology 33, no. 9 (August 2008): 2148–57. https://doi.org/10.1038/sj.npp.1301618.
McClernon, Francis J., et al. “Individual differences in nicotine dependence, withdrawal symptoms, and sex predict transient fMRI-BOLD responses to smoking cues.Neuropsychopharmacology, vol. 33, no. 9, Aug. 2008, pp. 2148–57. Pubmed, doi:10.1038/sj.npp.1301618.
McClernon FJ, Kozink RV, Rose JE. Individual differences in nicotine dependence, withdrawal symptoms, and sex predict transient fMRI-BOLD responses to smoking cues. Neuropsychopharmacology. 2008 Aug;33(9):2148–2157.
Journal cover image

Published In

Neuropsychopharmacology

DOI

ISSN

0893-133X

Publication Date

August 2008

Volume

33

Issue

9

Start / End Page

2148 / 2157

Location

England

Related Subject Headings

  • Tobacco Use Disorder
  • Surveys and Questionnaires
  • Smoking
  • Sex Characteristics
  • Psychiatry
  • Oxygen
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Individuality