Brain atrophy and cognitive deficits in Cushing's disease.


Journal Article (Review)

Cushing's disease is associated with brain atrophy and cognitive deficits. Excess glucocorticoids cause retraction and simplification of dendrites in the hippocampus, and this morphological change probably accounts for the hippocampal volume loss. Mechanisms by which glucocorticoids affect the brain include decreased neurogenesis and synthesis of neurotrophic factors, impaired glucose utilization, and increased actions of excitatory amino acids. In this review, the timing, pathology, and pathophysiology of the brain atrophy in Cushing's disease are discussed. The correlation of atrophy with cognitive deficits and its reversibility is also reviewed.

Full Text

Duke Authors

Cited Authors

  • Patil, CG; Lad, SP; Katznelson, L; Laws, ER

Published Date

  • 2007

Published In

Volume / Issue

  • 23 / 3

Start / End Page

  • E11 -

PubMed ID

  • 17961025

Pubmed Central ID

  • 17961025

Electronic International Standard Serial Number (EISSN)

  • 1092-0684

Digital Object Identifier (DOI)

  • 10.3171/foc.2007.23.3.13


  • eng

Conference Location

  • United States