Brain atrophy and cognitive deficits in Cushing's disease.
Published
Journal Article (Review)
Cushing's disease is associated with brain atrophy and cognitive deficits. Excess glucocorticoids cause retraction and simplification of dendrites in the hippocampus, and this morphological change probably accounts for the hippocampal volume loss. Mechanisms by which glucocorticoids affect the brain include decreased neurogenesis and synthesis of neurotrophic factors, impaired glucose utilization, and increased actions of excitatory amino acids. In this review, the timing, pathology, and pathophysiology of the brain atrophy in Cushing's disease are discussed. The correlation of atrophy with cognitive deficits and its reversibility is also reviewed.
Full Text
Duke Authors
Cited Authors
- Patil, CG; Lad, SP; Katznelson, L; Laws, ER
Published Date
- 2007
Published In
Volume / Issue
- 23 / 3
Start / End Page
- E11 -
PubMed ID
- 17961025
Pubmed Central ID
- 17961025
Electronic International Standard Serial Number (EISSN)
- 1092-0684
Digital Object Identifier (DOI)
- 10.3171/foc.2007.23.3.13
Language
- eng
Conference Location
- United States