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Risk factors for cerebrovascular events following fontan palliation in patients with a functional single ventricle.

Publication ,  Journal Article
Barker, PCA; Nowak, C; King, K; Mosca, RS; Bove, EL; Goldberg, CS
Published in: Am J Cardiol
August 15, 2005

The risk for cerebrovascular events (CVEs) is increased in children with functional single ventricles (FSVs). However, there are limited data indicating the prevalence of CVEs or the role of preventative therapy. To measure the prevalence of clinically evident CVEs in patients with FSVs, identify risk factors, and analyze the effect of aspirin on the risk for CVEs, a retrospective chart review was performed on all patients who underwent Fontan palliation at the University of Michigan from January 1, 1975, to June 30, 1998 (n = 402). Data collected included original anatomy, Fontan type, date of CVE, medications at the time of CVE, intraoperative placement of fenestration, and date of last follow-up. The overall mortality rate was 12%. There were 38 CVEs (9%), of which only 11 (3%, or 0.0036/patient-year) could not be attributed to a defined event (catheterization, extracorporeal membrane oxygenation, or cardiac arrest). Anticoagulation with aspirin was associated with a statistically significantly decreased risk for CVEs. Fontan type was not associated with the risk for CVEs. Thus, patients with FSVs are at increased risk for CVEs, although the de novo risk was low. Aspirin use is associated with a decreased risk for CVEs.

Duke Scholars

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

August 15, 2005

Volume

96

Issue

4

Start / End Page

587 / 591

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Survival Rate
  • Stroke
  • Risk Factors
  • Retrospective Studies
  • Prevalence
  • Platelet Aggregation Inhibitors
  • Palliative Care
  • Michigan
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Barker, P. C. A., Nowak, C., King, K., Mosca, R. S., Bove, E. L., & Goldberg, C. S. (2005). Risk factors for cerebrovascular events following fontan palliation in patients with a functional single ventricle. Am J Cardiol, 96(4), 587–591. https://doi.org/10.1016/j.amjcard.2005.04.025
Barker, Piers C. A., Cheryl Nowak, Karen King, Ralph S. Mosca, Edward L. Bove, and Caren S. Goldberg. “Risk factors for cerebrovascular events following fontan palliation in patients with a functional single ventricle.Am J Cardiol 96, no. 4 (August 15, 2005): 587–91. https://doi.org/10.1016/j.amjcard.2005.04.025.
Barker PCA, Nowak C, King K, Mosca RS, Bove EL, Goldberg CS. Risk factors for cerebrovascular events following fontan palliation in patients with a functional single ventricle. Am J Cardiol. 2005 Aug 15;96(4):587–91.
Barker, Piers C. A., et al. “Risk factors for cerebrovascular events following fontan palliation in patients with a functional single ventricle.Am J Cardiol, vol. 96, no. 4, Aug. 2005, pp. 587–91. Pubmed, doi:10.1016/j.amjcard.2005.04.025.
Barker PCA, Nowak C, King K, Mosca RS, Bove EL, Goldberg CS. Risk factors for cerebrovascular events following fontan palliation in patients with a functional single ventricle. Am J Cardiol. 2005 Aug 15;96(4):587–591.
Journal cover image

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

August 15, 2005

Volume

96

Issue

4

Start / End Page

587 / 591

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Survival Rate
  • Stroke
  • Risk Factors
  • Retrospective Studies
  • Prevalence
  • Platelet Aggregation Inhibitors
  • Palliative Care
  • Michigan
  • Male